Results 21 to 30 of about 12,856,576 (256)

Design of Extrusion Die for Medical Multi-lumen Tube Using Inverse Extrusion Simulation and Optimization [PDF]

한국정밀공학회지
The design of the extrusion die significantly affects both the extrusion process and the quality of multi-lumen tubes. Traditional design methods that rely on trial and error tend to increase manufacturing time and costs while diminishing product quality.
Yerim Kim, Kyungwook Ko, Wonjin Jun, Woojin Kim, Euntaek Lee   +4 more
doaj   +1 more source

Deduction of the operable design space of RP-HPLC technique for the simultaneous estimation of metformin, pioglitazone, and glimepiride

Scientific Reports, 2023
A reversed-phase RP-HPLC method was developed for the simultaneous determination of metformin hydrochloride (MET), pioglitazone (PIO), and glimepiride (GLM) in their combined dosage forms and spiked human plasma.
Aya A. Marie, Sherin F. Hammad, Mohamed M. Salim, Mahmoud M. Elkhodary, Amira H. Kamal   +4 more
doaj   +1 more source

Tablets Development Based on Clover Meadow Grass Phytosubstance Using Design of the Experiment Method and QdD Tools

Разработка и регистрация лекарственных средств, 2020
Introduction. Quality, along with efficacy and safety, are the key characteristics of a drug. Therefore, it is important in frame of pharmaceutical development to lay the foundation for obtaining a quality product and achieving the desired product ...
A. N. Golubev, Th. I. Nguen, V. V. Sorokin, I. E. Kauhova   +3 more
doaj   +1 more source

A systematic review of commercial high concentration antibody drug products approved in the US: formulation composition, dosage form design and primary packaging considerations

mAbs, 2023
Three critical aspects that define high concentration antibody products (HCAPs) are as follows: 1) formulation composition, 2) dosage form, and 3) primary packaging configuration. HCAPs have become successful in the therapeutic sector due to their unique
Indrajit Ghosh, Hiten Gutka, Mary E. Krause, Ryan Clemens, Ramesh S. Kashi   +4 more
doaj   +1 more source

Analytical QBD Approach to Redefine the Quality of Pharmaceuticals: A Review

Journal of Pharmaceutical Research, 2023
As per the present scenario traditional techniques of quality by testing of finished pharmaceutical products have proved to be unsatisfactory, although focus on 'Total quality assurance can be attained only by in-process testing and analysis ...
Shaik Ayesha Ameen, Nagaraju Pappula
doaj   +1 more source

Formulation and pharmaceutical development of quetiapine fumarate sustained release matrix tablets using a QbD approach

Acta Pharmaceutica, 2017
The main objective of the present study was to apply QbD methodology in the development of once-a-day sustained release quetiapine tablets. The quality target product profile (QTPP) was defined after the pharmaceutical properties and kinetic release of ...
Gavan Alexandru, Porfire Alina, Marina Cristina, Tomuta Ioan   +3 more
doaj   +1 more source

Analytical Quality by Design (AQbD) Approach to the Development of In Vitro Release Test for Topical Hydrogel

Pharmaceutics, 2022
The aim of our study was to adapt the analytical quality by design (AQbD) approach to design an effective in vitro release test method using USP apparatus IV with a semi-solid adapter (SSA) for diclofenac sodium hydrogel.
Réka Szoleczky, Mária Budai-Szűcs, Erzsébet Csányi, Szilvia Berkó, Péter Tonka-Nagy, Ildikó Csóka, Anita Kovács   +6 more
doaj   +1 more source

Macro- and Micro-Heterogeneity of Natural and Recombinant IgG Antibodies

Antibodies, 2019
Recombinant monoclonal antibodies (mAbs) intended for therapeutic usage are required to be thoroughly characterized, which has promoted an extensive effort towards the understanding of the structures and heterogeneity of this major class of molecules ...
Alain Beck, Hongcheng Liu
doaj   +1 more source

A Quality by Design Framework for Capsule-Based Dry Powder Inhalers

Pharmaceutics, 2021
Capsule-based dry powder inhalers (cDPIs) are widely utilized in the delivery of pharmaceutical powders to the lungs. In these systems, the fundamental nature of the interactions between the drug/formulation powder, the capsules, the inhaler device, and ...
Li Ding, Ashlee D. Brunaugh, Sven Stegemann, Scott V. Jermain, Matthew J. Herpin, Justin Kalafat, Hugh D. C. Smyth   +6 more
doaj   +1 more source

Target product profiles for digital health technologies including those with artificial intelligence: a systematic review

Frontiers in Health Services
Digital health technologies (DHTs), including those incorporating artificial intelligence (AI), have the potential to improve healthcare access, efficiency, and quality, reducing gaps between healthcare capacity and demand.
Trystan B. Macdonald, Trystan B. Macdonald, Trystan B. Macdonald, H. D. Jeffry Hogg, H. D. Jeffry Hogg, Jacqueline Dinnes, Jacqueline Dinnes, Lucy Verrinder, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, J. Kevin Dunbar, Ameenat Lola Solebo, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Felix Greaves, Carl Macrae, Carl Macrae, Russell Pearson, Adnan Tufail, Adnan Tufail, Xiaoxuan Liu, Xiaoxuan Liu, Xiaoxuan Liu, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston   +31 more
doaj   +1 more source