Results 61 to 70 of about 12,856,576 (256)

Hurdle technology for fish preservation

Aquaculture and Fisheries, 2020
Fresh fish is a highly perishable product due to the chemical composition of fish flesh and the high microbial load on fish surface. The natural microflora that is more adopted to low temperatures results also in lower thermal bacterial shock from ...
Theofania Tsironi, Dimitra Houhoula, Petros Taoukis   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

N-Glycosylation modulators for targeted manipulation of glycosylation for monoclonal antibodies

Applied Microbiology and Biotechnology
Monoclonal antibodies are extensively used as biotherapeutics for treatment of a variety of diseases. Glycosylation of therapeutic antibodies is considered a critical quality attribute as it influences the effector function, circulatory half-life ...
Neelesh Gangwar, Neha Dixit, Anurag S. Rathore   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Consumer Behavior: Product Characteristics and Quality Perception [PDF]

Consumers rely on signals, both extrinsic and intrinsic attributes, to solve their asymmetric information problem regarding product quality. In this study an experiment is designed to evaluate how consumers assess quality perception in terms of specific ...
Pires Gonçalves, Ricardo
core  

Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles

Frontiers in Bioengineering and Biotechnology, 2019
L-Asparaginase (ASNase) is a vital component of the first line treatment of acute lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over 53,000 people worldwide by 2020. More recently, ASNase has also been shown to have
Larissa Pereira Brumano, Francisco Vitor Santos da Silva, Tales Alexandre Costa-Silva, Alexsandra Conceição Apolinário, João Henrique Picado Madalena Santos, João Henrique Picado Madalena Santos, Eduardo Krebs Kleingesinds, Gisele Monteiro, Carlota de Oliveira Rangel-Yagui, Brahim Benyahia, Adalberto Pessoa Junior   +10 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

Pharmaceutics, 2020
3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing.
Patricija Januskaite, Xiaoyan Xu, Sejal R. Ranmal, Simon Gaisford, Abdul W. Basit, Catherine Tuleu, Alvaro Goyanes   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Inattentive consumers and product quality [PDF]

, 2007
This paper presents a model in which some consumers shop on the basis of price alone, without attention to product quality. A firm may “cheat” (i.e., cut quality) to exploit these inattentive consumers. In the unique symmetric equilibrium, firms follow a
Yongmin Chen, Chen, Y., Armstrong, Mark, Armstrong, M., Chen, Yongmin, Mark Armstrong   +5 more
core   +1 more source