Results 71 to 80 of about 12,856,576 (256)
Application of the Quality-by-Design Approach at the Laboratory Stage of Tablet Development
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. Quality by design (QbD) is a systematic approach to pharmaceutical development that begins with predefined objectives and emphasises product and process understanding and process control, based on sound science and quality risk management.
M. V. Karlina +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Gendered pounded yam product profile in Nigeria (1)
, 2022 The WP1 Gendered Food Product Profile for pounded yam in Nigeria reflects the final step of an interdisciplinary five-step methodology developed to identify demand for quality characteristics among diverse user groups along the food chain (Forsythe et al.
Madu, Tessy +3 more
core +1 more source
From lab to industrial development of lipid nanocarriers using quality by design approach
International Journal of Pharmaceutics: XLipid nanocarriers have attracted a great deal of interest in the delivery of therapeutic molecules. Despite their many advantages, compliance with quality standards and reproducibility requirements still constrain their industrial production.
Aristote B. Buya +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure of the target product profile (TPP) document.
, 2018 Structure of the target product profile (TPP) document.
Angela Watkins (3549089) +6 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Correlating motif analysis and morphological filters for surface texture analysis [PDF]
, 2013 In contrast to the mean-line based evaluation system, motif analysis and morphological filters are two techniques oriented to the characterization of functional properties of surfaces.
Lou, Shan +2 more
core +1 more source
Product Quality in the Canadian Dairy Industry [PDF]
Supply management has been shown to increase the price of milk. Technological change has induced (and allowed) processors to substitute alternative inputs, many of which can be imported tariff-free, for the traditional ingredients to lower costs and ...
Nogueira, Lia, Baylis, Katherine R.
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source