Results 81 to 90 of about 2,145,260 (311)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
amz78/Shape-uncertainty-quantification-for-TESLA-cavities: v1.0
Software for the paper "Shape uncertainty quantification of Maxwell eigenvalues and -modes with application to TESLA ...
amz78
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Notre Dame Journal of Formal Logic, 1990 A natural deduction system of quantified modal logic (S5) with an actuality operator and "rigid" quantifiers (ranging, at every world, over the domain of the actual world) is described and proved to be complete. Its motivation and relation to other systems are discussed. / The language Predicates. One logical predicate: E ! , "exists".
openaire +3 more sources
WorldThis article investigates issues in the local operationalization of the Planetary Boundaries concept (PBc), crucial for assessing human impacts on the Earth system and guiding sustainable development policies.
Damien Rieutor +3 more
doaj +1 more source
Phosphoproteomics technologies and applications in plant biology research
Frontiers in Plant Science, 2015 Protein phosphorylation has long been recognized as an essential mechanism to regulate many important processes of plant life. However, studies on phosphorylation mediated signaling events in plants are challenged with low stoichiometry and dynamic ...
Jinna eLi +6 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Journal of Fungi, 2018 The molecular detection of Pneumocystis jirovecii is an important therapy-relevant tool in microbiological diagnostics. However, the quantification of this pathogen in the past has revealed discordant results depending on the target gene. As the clinical
Cara Mia Dunaiski +6 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
ON QUANTIFICATION AND EXTENSIONALITY
The Review of Symbolic LogicAbstractWe investigate whether ordinary quantification over objects is an extensional phenomenon, or rather creates non-extensional contexts; each claim having been propounded by prominent philosophers. It turns out that the question only makes sense relative to a background theory of syntax and semantics (here called a grammar) that goes well beyond ...
openaire +2 more sources