Results 91 to 100 of about 204,570 (278)

An R Implementation of the Polya-Aeppli Distribution [PDF]

open access: yes, 2014
An efficient implementation of the Polya-Aeppli, or geometirc compound Poisson, distribution in the statistical programming language R is presented.
Burden, Conrad J.
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

Conditional quantile processes based on series or many regressors [PDF]

open access: yes
Quantile regression (QR) is a principal regression method for analyzing the impact of covariates on outcomes. The impact is described by the conditional quantile function and its functionals. In this paper we develop the nonparametric QR series framework,
Alexandre Belloni   +2 more
core  

Quantile Approximation of the Chi–square Distribution using the Quantile Mechanics [PDF]

open access: yes, 2017
In the field of probability and statistics, the quantile function and the quantile density function which is the derivative of the quantile function are one of the important ways of characterizing probability distributions and as well, can serve as a
Adamu, M. O.   +2 more
core  

Quantile‐locating functions and the distance between the mean and quantiles

open access: yesStatistica Neerlandica, 1993
Given a random variable X with finite mean, for each 0 < p < 1, a new sharp bound is found on the distance between a p‐quantile of X and its mean in terms of the central absolute first moment of X. The new bounds strengthen the fact that the mean of X is within one standard deviation of any of its medians, as well as a recent quantile ...
Gilat, D., Hill, Theodore P.
openaire   +3 more sources

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

open access: yesAdvanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova   +8 more
wiley   +1 more source

Parametric Modeling of Quantile Regression Coefficient Functions

open access: yesBiometrics, 2015
SummaryEstimating the conditional quantiles of outcome variables of interest is frequent in many research areas, and quantile regression is foremost among the utilized methods. The coefficients of a quantile regression model depend on the order of the quantile being estimated.
Frumento P, Bottai M
openaire   +4 more sources

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

open access: yesAdvanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng   +7 more
wiley   +1 more source

Generalized Method of Moments Estimator Based On Semiparametric Quantile Regression Imputation [PDF]

open access: yes, 2014
In this article, we consider an imputation method to handle missing response values based on semiparametric quantile regression estimation. In the proposed method, the missing response values are generated using the estimated conditional quantile ...
Chen, Senniang, Yu, Cindy L
core   +3 more sources

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

open access: yesAdvanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li   +13 more
wiley   +1 more source

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