Results 61 to 70 of about 27,716,395 (263)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Quantitative Analysis of Acoustic Emission Waveforms and Practical Application to Civil Structures in Japan [PDF]

, 1995
Recently, theoretical treatment is summarized as a generalized theory of AE [1]. It is clarified that crack kinetics and kinematics are recovered from a quantitative waveform analysis of AE.
M. Ohtsu, Ohtsu, M.
core   +1 more source

Rethinking Meta-Analytic Evidence in TAM-Based Research: From Pooled Effects to Generalizability in E-Banking Contexts

Journal of Theoretical and Applied Electronic Commerce Research
The Technology Acceptance Model (TAM) has been widely used to explain e-banking and digital technology adoption. Existing literature supports the robustness of its core relationships, but the magnitude of the effects varies considerably across studies ...
Elena Druică, Ionela-Andreea Puiu, Călin Vâlsan, Irena Munteanu   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Exploring Advanced Versions of Hermite-Hadamard and Trapezoid-Type Inequalities by Implementation of Fuzzy Interval-Valued Functions

Journal of Function Spaces
The extension of interval-valued and real-valued functions known as fuzzy interval-valued function (FIVF) has made substantial contributions to the theory of interval analysis.
Yaqun Niu, Rana Safdar Ali, Naila Talib, Shahid Mubeen, Gauhar Rahman, Çetin Yildiz, Fuad A. Awwad, Emad A. A. Ismail   +7 more
doaj   +1 more source

Observations from the U.S. Federal Income Tax to Distinguish Between Measures of Progressivity and Redistributive Capacity

Central European Public Administration Review, 2016
This study provides insights on the attributes of a tax that are measured by two different classes of progressivity indices – those defined by Kakwani (1977), Suits (1977), Stroup (2005), and Mathews (2016) and those defined by Musgrave & Thin (1948 ...
Timoty Mathews
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Evaluation of the fragility curve for steel structures with linked columns frame system under sequences of critical earthquakes

Discover Civil Engineering
Fragility curves as a powerful tool assess the possible damage to existing structures and estimate the probability of structural damage exceeding a given level of seismic damage for several levels of seismic ground motions.
Yaser Golestani, Elham Rajabi
doaj   +1 more source