Results 51 to 60 of about 3,500,762 (306)

Quantitative assessment of prefrontal cortex in humans relative to nonhuman primates [PDF]

open access: yes, 2018
Significance A longstanding controversy in neuroscience pertains to differences in human prefrontal cortex (PFC) compared with other primate species; specifically, is human PFC disproportionately large? Distinctively human behavioral capacities
Donahue, Chad J.   +4 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Uncertainty-aware machine learning to predict non-cancer human toxicity for the global chemicals market

open access: yesNature Communications
Humans are exposed to thousands of chemicals, yet limited toxicity data hinder effective management of their impacts on human health. High-performing machine learning models hold potential for addressing this gap, but their uncharacterized prediction ...
Kerstin von Borries   +5 more
doaj   +1 more source

Risk assessment of water inrush caused by karst cave in tunnels based on reliability and GA-BP neural network

open access: yesGeomatics, Natural Hazards & Risk, 2020
In order to evaluate the risk level of water inrush caused by karst cave accurately and effectively, a novel quantitative assessment model was established based on the reliability theory and genetic algorithm-back propagation (GA-BP) neural network ...
Zhaoyang Li   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Towards reliable national social footprints: refining work-related injury and fatality metrics

open access: yesDiscover Sustainability
Objectives The objective of this data note is to provide a reliable, comprehensive dataset focusing on work-related injuries and fatalities, broken down by year, country, gender, and economic sector.
Etienne Berthet   +3 more
doaj   +1 more source

Defect Width Assessment Based on the Near-Field Magnetic Flux Leakage Method

open access: yesSensors, 2021
Magnetic flux leakage (MFL) testing has been widely used as a non-destructive testing method for various materials. However, it is difficult to separate the influences of the defect geometrical parameters such as depth, width, and length on the received ...
Erlong Li   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Toward soil health assessment in a life cycle perspective: Linking soil stressors to damage to ecosystem services

open access: yesGeoderma
Healthy soils are essential for life on Earth and a prerequisite for maintaining various important ecosystem services. As a result, management recommendations to improve soil health are increasingly being incorporated into legislation. Several frameworks
Patricia Gilarte   +3 more
doaj   +1 more source

EU-India free trade agreement : a quantitative assessment [PDF]

open access: yes, 2008
This report analyses the effects of a regional trade agreement (FTA) between the EU and India, for which negotiations are underway. The study starts with abrief overview of the key insights from the existing literature on FTAs and their relationship with
Achterbosch, T.J.   +2 more
core   +1 more source

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