Results 51 to 60 of about 8,273,226 (310)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Challenges of quantitative microbial risk assessment at EU level. [PDF]

, 2009
Quantitative microbial risk assessment (QMRA) aims to model the fate of pathogenic micro-organisms along the food chain and the associated health risks.
Evers, E.G., Nauta, M.J., Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Havelaar, A.H.   +4 more
core  

Guidelines to Evaluate Human Observational Studies for Quantitative Risk Assessment [PDF]

, 2008
Background: Careful evaluation of the quality of human observational studies (HOS) is required to assess the suitability of HOS for quantitative risk assessment (QRA) . In particular, the quality of quantitative exposure assessment is a crucial aspect of
Heederik, D., Vlaanderen, J.J., Roel Vermeulen, Jelle Vlaanderen, Vermeulen, R.C.H., Dick Heederik, Hans Kromhout, Kromhout, H.   +7 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Potential Climate Change Impacts on the Abiotic Degradation of Acyl-Homoserine Lactones in the Fluctuating Conditions of Marine Biofilms

Frontiers in Marine Science, 2022
Marine biofilms are functional communities that shape habitats by providing a range of structural and functional services integral to coastal ecosystems.
Christina C. Roggatz, Daniel R. Parsons
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Beyond net zero climate targets: a research agenda for absolute environmental sustainability assessment to support decisions at different scales

Environmental Research Letters
Recent years have seen a wave of net zero targets for greenhouse gas emissions. These represent translations of the Paris Agreement goal of limiting global warming to well below 2 °C to targets for central actors, such as countries, cities and companies.
Anders Bjørn, Peter Fantke, Michael Zwicky Hauschild, Olivier Jolliet, Alexis Laurent, Mikolaj Owsianiak, Morten Ryberg, Eldbjørg Blikra Vea   +7 more
doaj   +1 more source

Quantitative assessment of the genotoxicity of fecapentaenes

Mutation Research/Genetic Toxicology, 1991
Fecapentaenes are a group of fecal mutagens of microbial origin isolated from human stools. Fecapentaene-12 (F-12) and fecapentaene-14 (F-14), differing only in two carbon atoms in the side chain, are glyceryl ethers with a highly reactive chromophoric aliphatic side chain incorporating a conjugated pentaene moiety.
P P, Nair, S, Shami, E, Sainz, J T, Judd, P R, Taylor, A, Schatzkin   +5 more
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Molecularly generated rat hepatitis E virus strains from human and rat show efficient replication in a human hepatoma cell line

Virus Research
The hepatitis E virus (HEV) can cause acute and chronic hepatitis in humans. Whereas HEV genotypes 1–4 of species Paslahepevirus balayani are commonly found in humans, infections with ratHEV (species Rocahepevirus ratti) were previously considered to be ...
Jessica Panajotov, Alexander Falkenhagen, Ashish K. Gadicherla, Reimar Johne   +3 more
doaj   +1 more source