Results 71 to 80 of about 8,273,226 (310)

Toward soil health assessment in a life cycle perspective: Linking soil stressors to damage to ecosystem services

Geoderma
Healthy soils are essential for life on Earth and a prerequisite for maintaining various important ecosystem services. As a result, management recommendations to improve soil health are increasingly being incorporated into legislation. Several frameworks
Patricia Gilarte, Amila Abeynayaka, Peter Fantke, Mikołaj Owsianiak   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identifying options for additionality tests in the context of scope 2 market-based accounting

Carbon Management
The current greenhouse gas accounting rules for reporting emissions associated with electricity consumption (known as ‘scope 2’ emissions) have been criticised for failing to differentiate between impactful and non-impactful actions, and for producing ...
Malte Schäfer, Caroline Herlev Gebara, Anders Bjørn, Matthew Brander   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

[F-18] FDG-PET/CT parameters as predictors of outcome in inoperable NSCLC patients

Radiology and Oncology, 2015
Background. We evaluated the prognostic significance of standardized uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) in [F-18] FDG PET/CT findings in patients with inoperable non-small-cell lung cancer (NSCLC).
Nappi Antonio, Gallicchio Rosj, Simeon Vittorio, Nardelli Anna, Pelagalli Alessandra, Zupa Angela, Vita Giulia, Venetucci Angela, Di Cosola Michele, Barbato Francesco, Storto Giovanni   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Influence of Social-economic Activities on Air Pollutants in Beijing, China

Open Geosciences, 2017
With the rapid economic development, the serious air pollution in Beijing attracts increasing attention in the last decade. Seen as one whole complex and grey system, the causal relationship between the social development and the air pollution in Beijing
Li Xiaolu, Zheng Wenfeng, Yin Lirong, Yin Zhengtong, Song Lihong, Tian Xia   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A New "Intersection" Method for Multi-Objective Optimization in Material Selection

Tehnički Glasnik, 2021
Till now the previous methods for multi-objective optimization adopt the "additive" algorithm for the normalized evaluation indexes, which has the inherent shortcoming of taking the form of "union" in the viewpoint of set theory.
Maosheng Zheng, Yi Wang, Haipeng Teng
doaj