Results 61 to 70 of about 3,500,762 (306)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identifying options for additionality tests in the context of scope 2 market-based accounting

Carbon Management
The current greenhouse gas accounting rules for reporting emissions associated with electricity consumption (known as ‘scope 2’ emissions) have been criticised for failing to differentiate between impactful and non-impactful actions, and for producing ...
Malte Schäfer, Caroline Herlev Gebara, Anders Bjørn, Matthew Brander   +3 more
doaj   +1 more source

Photoplethysmography for Quantitative Assessment of Sympathetic Nerve Activity (SNA) During Cold Stress [PDF]

, 2019
The differences in the degree of sympathetic nerve activity (SNA) over cutaneous blood vessels, although known to be more prominent in the periphery than the core vasculature, has not been thoroughly investigated quantitatively.
Ainslie, Anderson, Appelhans, Billman, Budidha, Budidha, Budidha, Budidha, Burgess, Busija, Daanen, Deng, Eigsti, Esler, Flavahan, Folk, Gordon, Guild, Hart, Hernandez, Hodges, Kaciuba-Uscilko, Korhonen, Kyriacou, Nitzan, Nitzan, Nitzan, Pagani, Penzel, Ramchandra, Reed, Seravalle, Shelley, Silverthorn, Sinski, Smith, Stocks, Tansey, ter Laan, Thayer, Vallbo, Van Vliet, Venema, Wehrwein   +43 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

[F-18] FDG-PET/CT parameters as predictors of outcome in inoperable NSCLC patients

Radiology and Oncology, 2015
Background. We evaluated the prognostic significance of standardized uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) in [F-18] FDG PET/CT findings in patients with inoperable non-small-cell lung cancer (NSCLC).
Nappi Antonio, Gallicchio Rosj, Simeon Vittorio, Nardelli Anna, Pelagalli Alessandra, Zupa Angela, Vita Giulia, Venetucci Angela, Di Cosola Michele, Barbato Francesco, Storto Giovanni   +10 more
doaj   +1 more source

Architecture-based Qualitative Risk Analysis for Availability of IT Infrastructures [PDF]

, 2009
An IT risk assessment must deliver the best possible quality of results in a time-effective way. Organisations are used to customise the general-purpose standard risk assessment methods in a way that can satisfy their requirements.
Etalle, Sandro, Hartel, Pieter H., Wieringa, Roelf J., Zambon, Emmanuele, Zambon, Emmanuele   +4 more
core   +2 more sources

Factors affecting academic performance of international students in project management courses : a case study from a British Post 92 University [PDF]

, 2008
Original article can be found at : http://www.sciencedirect.com/ Copyright ElsevierThe aim of study is to investigate the factors affecting the academic performance of international students in Project Management courses.
Lebcir, Mohamed, Wells, Hany, Bond, Angela   +2 more
core   +7 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Influence of Social-economic Activities on Air Pollutants in Beijing, China

Open Geosciences, 2017
With the rapid economic development, the serious air pollution in Beijing attracts increasing attention in the last decade. Seen as one whole complex and grey system, the causal relationship between the social development and the air pollution in Beijing
Li Xiaolu, Zheng Wenfeng, Yin Lirong, Yin Zhengtong, Song Lihong, Tian Xia   +5 more
doaj   +1 more source