Results 81 to 90 of about 3,500,762 (306)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Classroom games in economics : a quantitative assessment of the 'beer game' [PDF]

, 2011
Using an experiment, I compare the use of the 'Beer Distribution' classroom game with the more traditional 'chalk and talk' approach to teach students about inventories and the macroeconomy.
McMahon, Michael F.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Quantifying water erosion’s impact on soil productivity of croplands in China

National Science Open
Soil degradation in croplands caused by water erosion significantly threatens food security. However, quantitative effects of current and future water erosion on soil productivity in croplands remain uncertain.
Yang Xue, Duan Xingwu, Liu Baoyuan, Xie Yun, Siemann Evan, Wang Hongna, Zhang Enwei, Rong Li, Li Yawen, Feng Detai, Lv Huanxu   +10 more
doaj   +1 more source

On Flight Risk Analysis Method Based on Stability Region of Dynamic System Under Icing Conditions

IEEE Access, 2020
The occurrence of loss of control in flight is often accompanied by deep coupling of flight parameters. In order to explore the mechanism of coupling induced flight risk, a method of flight risk assessment based on the stability region of a nonlinear ...
Zhe Li, Xiaocong Duan, Xiaogang Li, Shihao Wang, Yanyan Hou   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Cross-Spatiotemporal Graph Convolution Networks for Skeleton-Based Parkinsonian Gait MDS-UPDRS Score Estimation

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Gait impairment in Parkinson’s Disease (PD) is quantitatively assessed using the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), a well-established clinical tool. Objective and efficient PD gait assessment is
Haoyu Tian, Haiyun Li, Wenjing Jiang, Xin Ma, Xiang Li, Hanbo Wu, Yibin Li   +6 more
doaj   +1 more source

Quantitative Assessment of Desertification Using Landsat Data on a Regional Scale – A Case Study in the Ordos Plateau, China

Sensors, 2009
Desertification is a serious threat to the ecological environment and social economy in our world and there is a pressing need to develop a reasonable and reproducible method to assess it at different scales. In this paper, the Ordos Plateau in China was
Jianjun Pan, Dongsheng Qiu, Xiangwu Kang, Duanyang Xu, Dafang Zhuang   +4 more
doaj   +1 more source

Challenges in Risk Assessment: Quantitative Risk Assessment

Procedia Food Science, 2016
AbstractThe process of risk analysis consists out of three components, risk assessment, risk management and risk communication. These components are internationally well spread by Codex Alimentarius Commission as being the basis for setting science based standards, criteria on food safety hazards, e.g. setting maximum limits of mycotoxins in foodstuffs.
Jacxsens, Liesbeth, Uyttendaele, Mieke, De Meulenaer, Bruno   +2 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source