Results 1 to 10 of about 355,279 (98)

Modern views of ancient metabolic networks [PDF]

, 2018
Metabolism is a molecular, cellular, ecological and planetary phenomenon, whose fundamental principles are likely at the heart of what makes living matter different from inanimate one. Systems biology approaches developed for the quantitative analysis of
Goldford, Joshua E., Segrè, Daniel
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Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
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Mind-life continuity: a qualitative study of conscious experience [PDF]

, 2017
There are two fundamental models to understanding the phenomenon of natural life. One is thecomputational model, which is based on the symbolic thinking paradigm. The other is the biologicalorganism model.
Hipólito, Inês, Martins, J.
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Formal executable descriptions of biological systems [PDF]

, 2005
The similarities between systems of living entities and systems of concurrent processes may support biological experiments in silico. Process calculi offer a formal framework to describe biological systems, as well as to analyse their behaviour, both ...
Brodo, Linda, Curti, Michele, Degano, Pierpaolo, Prandi, Davide, Priami, Corrado, Quaglia, Paola   +5 more
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Mechanical and Systems Biology of Cancer [PDF]

, 2018
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival.
Bakal, Chris, Mak, Michael, Spill, Fabian   +2 more
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A structured approach for the engineering of biochemical network models, illustrated for signalling pathways [PDF]

, 2008
http://dx.doi.org/10.1093/bib/bbn026Quantitative models of biochemical networks (signal transduction cascades, metabolic pathways, gene regulatory circuits) are a central component of modern systems biology.
Alves, Breitling, Brown, D. Gilbert, Fisher, Huang, Hucka, Kholodenko, Kholodenko, Kolch, Levchenko, M. Heiner, Mendes, Orton, R. Breitling, R. Orton, Schoeberl, Wiley   +17 more
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InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]

, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Breuer, Karin, Brinkman, Fiona S. L., Chen, Carol, Foroushani, Amir K., Hancock, Robert E.W., Laird, Matthew R, Lo, Raymond, Lynn, David J, Sribnaia, Anastasia, Winsor, Geoffrey L   +9 more
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Stochastic Physics, Complex Systems and Biology [PDF]

, 2012
In complex systems, the interplay between nonlinear and stochastic dynamics, e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in Darwinian sense, in terms of discrete jumps among attractors, with punctuated equilibrium ...
A Lasota, B Alberts, B E Shapiro, C Bustamante, D A Beard, D Hanahan, D-Q Jiang, E V Koonin, H D I Abarbanel, H Ge, H Ge, H Ge, H Ge, H Ge, H Haken, H Qian, H Qian, H Qian, H Qian, H Qian, H Qian, H Qian, H Tong, H V Westerhoff, I Prigogine, J J Hopfield, J Knight, J Monod, J Wang, J Wang, J Wang, L Bertalanffy Von, L Cai, L Onsager, M B Elowitz, M C Mackey, M W Kirschner, N Wax, P Ao, P Ao, P Ao, P B Moore, R F Fox, R Phillips, W J Ewens, X-J Zhang   +45 more
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Detection of regulator genes and eQTLs in gene networks

, 2016
Genetic differences between individuals associated to quantitative phenotypic traits, including disease states, are usually found in non-coding genomic regions.
A Butte, A Chatr-Aryamontri, A Clauset, A Joshi, A Joshi, A Kundaje, AA Shabalin, AJ Enright, AJ Walhout, AS Dimas, B Schwanhausser, B Zhang, B Zhang, C Cenik, CO Daub, D Koller, DA Cusanovich, DM Greenawalt, E Bonnet, E Ravasz, E Segal, EC Neto, EC Neto, EC Neto, EE Schadt, EE Schadt, EE Schadt, EE Schadt, EE Schadt, EJ Foss, F Grubert, F Yue, FA Cubillos, FW Albert, G Hemani, G Nicholson, GD Smith, GH Golub, H Foroughi Asl, H Talukdar, HN Kadarmideen, J Millstein, J Qi, J Zhu, J Zhu, J Zhu, JE Aten, JF Ayroles, JJ Faith, JL Björkegren, JS Liu, K Basso, K Qu, KG Ardlie, L Wu, LA Hindorff, LH Hartwell, LS Chen, M Ashburner, M Civelek, M Georges, M Gerstein, M Medvedovic, M Schmidt, M Scutari, MA Schaub, MB Eisen, MD Ritchie, ME Goddard, MEJ Newman, MEJ Newman, MV Rockman, MV Rockman, N Friedman, N Friedman, N Friedman, N Laird, O Stegle, P Langfelder, P Langfelder, P Langfelder, P Lu, R Sharan, R Sharan, RB Brem, RW Williams, S Lee, S Roy, S Tavazoie, SI Lee, SM Waszak, SS Rao, T Lappalainen, T Michoel, TA Manolio, TF Mackay, The ENCODE, TS Furey, VG Cheung, W Cookson, W Zhang, Y Chen, Y Li   +102 more
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Design and Development of Software Tools for Bio-PEPA [PDF]

, 2009
This paper surveys the design of software tools for the Bio-PEPA process algebra. Bio-PEPA is a high-level language for modelling biological systems such as metabolic pathways and other biochemical reaction networks.
Duguid, Adam, Gilmore, Stephen, Guerriero, Maria, Hillston, Jane, Loewe, Laurence   +4 more
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