Results 11 to 20 of about 183,000 (118)
Multi-omics integration reveals molecular networks and regulators of psoriasis
BMC Systems Biology, 2019 BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Yuqi Zhao +5 more
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A quantitative tissue-specific landscape of protein redox regulation during aging
Cell, 2020 Summary Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS).
Haopeng Xiao +19 more
semanticscholar +1 more source
Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae
Translational Medicine of Aging, 2019 Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and cancer. Therefore,
R. O'Laughlin +6 more
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Characterization of Gene Regulatory Networks in Plants Using New Methods and Data Types.
Methods in molecular biology, 2023 A major question in plant biology is to understand how plant growth, development, and environmental responses are controlled and coordinated by the activities of regulatory factors.
Klaas Vandepoele, Kerstin Kaufmann
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bioRxiv, 2021 We present the first example of in vivo high-resolution mass spectrometry (HRMS) for subcellular molecular systems biology of proteins and metabolites. With light microscopy, we identified the left-dorsal and left-ventral animal cells in cleavage-stage ...
Camille Lombard‐Banek +7 more
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In vivo quantitative high-throughput screening for drug discovery and comparative toxicology
bioRxiv, 2022 Quantitative high-throughput screening (qHTS) evaluates the pharmacology of drug and investigational agent libraries for potential therapeutic uses, toxicological risk assessment, and increasingly for academic chemical tool discovery.
P. Dranchak +8 more
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Multiscale Solutions to Quantitative Systems Biology Models
Frontiers in Molecular Biosciences, 2019 Systems biology implements a variety of statistical, computational and mathematical techniques to understand how networks of biological systems work together to achieve a function (Westerhoff and Palsson, 2004; Wolkenhauer, 2014).
Nehemiah T. Zewde
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A gene ontology inferred from molecular networks
Nature Biotechnology, 2012 Ontologies have proven very useful for capturing knowledge as a hierarchy of terms and their interrelationships. In biology a major challenge has been to construct ontologies of gene function given incomplete biological knowledge and inconsistencies in ...
Janusz Dutkowski +8 more
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RNA-RNA competitive interactions: a molecular civil war ruling cell physiology and diseases
Exploration of Medicine, 2023 The idea that proteins are the main determining factors in the functioning of cells and organisms, and their dysfunctions are the first cause of pathologies, has been predominant in biology and biomedicine until recently.
C. Barbagallo +7 more
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Molecular Carcinogenesis, 2023 An anticancer drug known as Rapamycin acts by inhibiting the mammalian target of the Rapamycin pathway. This agent has recently been investigated for its potential therapeutic benefits in sensitizing drug‐resistant breast cancer (BC) treatment.
Ali Tafti +5 more
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