Results 11 to 20 of about 181,187 (218)

Multi-omics integration reveals molecular networks and regulators of psoriasis

BMC Systems Biology, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Yuqi Zhao, D. Jhamb, L. Shu, Douglas V. Arneson, D. Rajpal, Xia Yang   +5 more
semanticscholar   +1 more source

A quantitative tissue-specific landscape of protein redox regulation during aging

Cell, 2020
Summary Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS).
Haopeng Xiao, Mark P. Jedrychowski, Devin K. Schweppe, Edward L. Huttlin, Qing Yu, D. Heppner, Jiaming Li, J. Long, E. Mills, John Szpyt, Zhixiang He, Guangyan Du, Ryan Garrity, A. Reddy, L. P. Vaites, J. Paulo, Tinghu Zhang, N. Gray, S. Gygi, Edward T. Chouchani   +19 more
semanticscholar   +1 more source

Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks.

Trends in Genetics, 2021
The adaptation of populations to local environments often relies on the selection of optimal values for polygenic traits. Here, we first summarize the results obtained from different quantitative genetics and population genetics models, about the genetic
M. Fagny, F. Austerlitz
semanticscholar   +1 more source

Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

Translational Medicine of Aging, 2019
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and cancer. Therefore,
R. O'Laughlin, Meng Jin, Yang Li, L. Pillus, L. Tsimring, J. Hasty, Nan Hao   +6 more
semanticscholar   +1 more source

In Vivo Subcellular Mass Spectrometry Enables Proteo-Metabolomic Single-cell Systems Biology in a Chordate Embryo Developing to a Normally Behaving Tadpole (X. laevis)

bioRxiv, 2021
We present the first example of in vivo high-resolution mass spectrometry (HRMS) for subcellular molecular systems biology of proteins and metabolites. With light microscopy, we identified the left-dorsal and left-ventral animal cells in cleavage-stage ...
Camille Lombard‐Banek, Jie Li, Erika P. Portero, R. Onjiko, Chase D. Singer, David O. Plotnick, Reem Q. Al Shabeeb, P. Nemes   +7 more
semanticscholar   +1 more source

Multiscale Solutions to Quantitative Systems Biology Models

Frontiers in Molecular Biosciences, 2019
Systems biology implements a variety of statistical, computational and mathematical techniques to understand how networks of biological systems work together to achieve a function (Westerhoff and Palsson, 2004; Wolkenhauer, 2014).
Nehemiah T. Zewde
semanticscholar   +1 more source

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

bioRxiv, 2022
Quantitative high-throughput screening (qHTS) evaluates the pharmacology of drug and investigational agent libraries for potential therapeutic uses, toxicological risk assessment, and increasingly for academic chemical tool discovery.
P. Dranchak, E. Oliphant, B. Queme, L. Lamy, Yuhong Wang, Ruili Huang, M. Xia, Dingyin Tao, James Inglese   +8 more
semanticscholar   +1 more source

RNA-RNA competitive interactions: a molecular civil war ruling cell physiology and diseases

Exploration of Medicine, 2023
The idea that proteins are the main determining factors in the functioning of cells and organisms, and their dysfunctions are the first cause of pathologies, has been predominant in biology and biomedicine until recently.
C. Barbagallo, M. Stella, C. Ferrara, A. Caponnetto, R. Battaglia, D. Barbagallo, C. Di Pietro, M. Ragusa   +7 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A systems biology approach and in vitro experiment indicated Rapamycin targets key cancer and cell cycle‐related genes and miRNAs in triple‐negative breast cancer cells

Molecular Carcinogenesis, 2023
An anticancer drug known as Rapamycin acts by inhibiting the mammalian target of the Rapamycin pathway. This agent has recently been investigated for its potential therapeutic benefits in sensitizing drug‐resistant breast cancer (BC) treatment.
Ali Tafti, Samaneh Shojaei, H. Zali, Saeed Karima, Samira Mohammadi-Yeganeh, M. Mondanizadeh   +5 more
semanticscholar   +1 more source