Results 11 to 20 of about 9,663,311 (207)

Representing and analysing molecular and cellular function in the computer [PDF]

open access: yes, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Wodak, SJ   +6 more
core   +7 more sources

Machine learning in systems biology at different scales : from molecular biology to ecology [PDF]

open access: yes, 2015
Machine learning has been a source for continuous methodological advances in the field of computational learning from data. Systems biology has profited in various ways from machine learning techniques but in particular from network inference, i.e. the
Aderhold, Andrej
core   +2 more sources

Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology [PDF]

open access: yes, 2009
The use of computational modeling and simulation has increased in many biological fields, but despite their potential these techniques are only marginally applied in nutritional sciences.
Ommen, Ben van   +57 more
core   +3 more sources

Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data [PDF]

open access: yes, 2006
As one of the most recent members of the omics family, large-scale quantitative metabolomics data are currently complementing our systems biology data pool and offer the chance to integrate the metabolite level into the functional analysis of cellular ...
Panke, Sven   +9 more
core   +7 more sources

Curating the innate immunity interactome [PDF]

open access: yes, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R   +34 more
core   +1 more source

When kinases meet mathematics: the systems biology of MAPK signalling [PDF]

open access: yes, 2005
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified ...
Calder, M.   +5 more
core   +1 more source

What is quantitative plant biology? [PDF]

open access: yes, 2021
Quantitative plant biology is an interdisciplinary field that builds on a long history of biomathematics and biophysics. Today, thanks to high spatiotemporal resolution tools and computational modelling, it sets a new standard in plant science ...
Bassel, George, W   +68 more
core   +2 more sources

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]

open access: yes, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Brinkman, Fiona S. L.   +19 more
core   +1 more source

Systems Biology and the Integration of Mechanistic Explanation and Mathematical Explanation [PDF]

open access: yes, 2013
The paper discusses how systems biology is working toward complex accounts that integrate explanation in terms of mechanisms and explanation by mathematical models—which some philosophers have viewed as rival models of explanation.
Brigandt, Ingo
core   +1 more source

Evolution under Fluctuating Environments Explains Observed Robustness in Metabolic Networks [PDF]

open access: yes, 2010
Copyright: © 2010 Soyer, Pfeiffer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Pfeiffer, Thomas   +6 more
core   +1 more source

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