Results 21 to 30 of about 183,000 (118)
Understanding Modularity in Molecular Networks Requires Dynamics
Science Signaling, 2009 Relating structure and dynamics of molecular networks remains very challenging. The era of genome sequencing has produced long lists of the molecular parts from which cellular machines are constructed.
Roger P. Alexander +3 more
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Information Processing in Biochemical Networks.
Annual Review of BiophysicsLiving systems are characterized by controlled flows of matter, energy, and information. While the biophysics community has productively engaged with the first two, addressing information flows has been more challenging, with some scattered success in ...
G. Tkačik, P. T. Wolde
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Espert Review of Proteomics, 2020 Introduction Metabolomics has become a crucial part of systems biology; however, data analysis is still often undertaken in a reductionist way focusing on changes in individual metabolites. Whilst such approaches indeed provide relevant insights into the
Leonardo Perez de Souza +3 more
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Genome Biology, 2019 Deep learning has emerged as a versatile approach for predicting complex biological phenomena. However, its utility for biological discovery has so far been limited, given that generic deep neural networks provide little insight into the biological ...
N. Fortelny, C. Bock
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Quant. Biol.Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single ...
Hetian Su, Nan Hao
semanticscholar +1 more source
Journal of Advances in Biology & BiotechnologyEnvironmental stresses, including drought, salinity, temperature extremes, and pathogen attacks, severely limit global agricultural productivity by disrupting plant growth, metabolism, and reproduction.
R. S. S. H. G. Alapati +6 more
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BMC Systems Biology, 2015 BackgroundCellular decision-making is governed by molecular networks that are highly complex. An integrative understanding of these networks on a genome wide level is essential to understand cellular health and disease.
Tomoya Mori +4 more
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Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis
International Journal of Molecular Sciences, 2019 MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple steps, including the transcription of primary miRNAs (pri-miRNAs), nuclear ...
Hironori Matsuyama, Hiroshi I. Suzuki
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Inferring Interaction Networks From Multi-Omics Data
Frontiers in Genetics, 2019 A major goal in systems biology is a comprehensive description of the entirety of all complex interactions between different types of biomolecules—also referred to as the interactome—and how these interactions give rise to higher, cellular and organism ...
Johann S. Hawe +2 more
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Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks
Cell Communication and Signaling, 2013 A central goal of systems biology is the construction of predictive models of bio-molecular networks. Cellular networks of moderate size have been modeled successfully in a quantitative way based on differential equations.
Regina Samaga, Steffen Klamt
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