Results 31 to 40 of about 377,168 (131)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A benign juvenile environment reduces the strength of antagonistic pleiotropy and genetic variation in the rate of senescence [PDF]

, 2015
The environment can play an important role in the evolution of senescence because the optimal allocation between somatic maintenance and reproduction depends on external factors influencing life expectancy.
Gonzalez G., Medawar P.B., Pigliucci M., Schlichting C.D.   +3 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Bridging the gap between omics and earth system science to better understand how environmental change impacts marine microbes [PDF]

, 2015
The advent of genomic-, transcriptomic- and proteomic-based approaches has revolutionized our ability to describe marine microbial communities, including biogeography, metabolic potential and diversity, mechanisms of adaptation, and phylogeny and ...
Alexander, Allen, Alvain, Ashworth, Baas-Becking, Bach, Barton, Behrenfeld, Behrenfeld, Behrenfeld, Bennett, Bihan, Bochdanovits, Bopp, Bowler, Boyd, Boyd, Boyle, Bruggeman, Buitenhuis, Buitenhuis, Buitenhuis, Button, Chappell, Coesel, Coleman, Collins, Corellou, Daines, Davis, Delong, Derelle, Deutsch, Dinsdale, Djouani-Tahri el, Doney, Draghi, Dufresne, Dutkiewicz, Edwards, Elena, Fabris, Follows, Follows, Franklin, Ghiglione, Gilbert, Gould, Hartmann, Hashioka, Hickman, Hillebrand, Hindle, Hof, Hood, House, Hutchins, Huysman, Hüner, Johnson, Juhas, Juranek, Kashtan, Kim, Kiorboe, Knoop, Kroeker, Krumholz, Ladau, Lanfear, Langer, Laws, Ley, Lindell, Litchman, Litchman, Loeuille, Lohbeck, Luo, Marchetti, Marinov, Martiny, Masotti, McKew, Mock, Monnier, Monteiro, Moore, Moulager, O'Neill, Oschlies, Patel, Piotrowski, Plummer, Poloczanaska, Quere, Raes, Ral, Raven, Raven, Raymond, Reed, Ridgwell, Riley, Rocap, Saito, Schaum, Schlichting, Schmidt, Shuter, Smetacek, Sorokina, Steuer, Stramma, Talmy, Taucher, Taylor, Thomas, Toseland, Traylor-Knowles, Troein, Vallino, Veluchamy, Via, Vogt, Vu, Webb, Wecker, Wijffels, Zinser   +129 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Future trends in Animal Breeding due to new genetic tecnologies

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
core   +1 more source

20 questions on Adaptive Dynamics [PDF]

, 2005
Adaptive Dynamics is an approach to studying evolutionary change when fitness is density or frequency dependent. Modern papers identifying themselves as using this approach first appeared in the 1990s, and have greatly increased up to the present ...
Abrams, Abrams, Abrams, Altenberg, Arnold, Asmussen, Asmussen, Avise, Barton, Bolnick, Bulmer, Bulmer, Bürger, Bürger, Caisse, Christiansen, Christiansen, Cockerham, Crosby, Crow, Crow, D. WAXMAN, Dickinson, Dieckmann, Dieckmann, Diehl, Doebeli, Dooren, Dooren, Doorn, Doorn, Endler, Eshel, Eshel, Fear, Felsenstein, Fisher, Gavrilets, Gavrilets, Gavrilets, Gavrilets, Geritz, Geritz, Geritz, Ginzburg, Haldane, Hofbauer, Kimura, Kingman, Kisdi, Kostitzin, Lande, Lewontin, Ludwig, Marks, Matessi, Matessi, Matsuda, Maynard Smith, Metz, Metz, Mizera, Moore, Moore, Mylius, Nowak, Orr, Orr, Provine, Provine, Reed, Rice, Roughgarden, Roughgarden, S. GAVRILETS, Schaffer, Slatkin, Slatkin, Slatkin, Spencer, Spencer, Taylor, Tienderen, Turelli, Udovic, Vincent, Waxman, Welch, Wilson, Wright, Wright, Zeng   +91 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source