Results 51 to 60 of about 3,561 (165)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Community impacts of anthropogenic disturbance: natural enemies exploit multiple routes in pursuit of invading herbivore hosts [PDF]

, 2010
Background: Biological invasions provide a window on the process of community assembly. In particular, tracking natural enemy recruitment to invading hosts can reveal the relative roles of coevolution (including local adaptation) and ecological sorting ...
Hayward Alexander, Juli Pujade-Villar, Fuentes-Utrilla, Pablo, Nieves-Aldrey, Jose-Luis, Nieves-Aldrey José-Luis, Nieves-Aldrey, J. L., Stone Graham N, Graham N Stone, Hayward, Alexander, Tavakoli Majid, Melika George, Schoenrogge, Karsten, Pablo Fuentes-Utrilla, György Csóka, Csoka, Gyoergy, Melika, George, George Melika, Tavakoli, Majid, Pujade-Villar Juli, Nicholls James A, Schonrogge, Karsten, Csóka György, Alexander Hayward, José-Luis Nieves-Aldrey, Nicholls, James A., Schönrogge Karsten, Majid Tavakoli, Csoka, Gyorgy, James A Nicholls, Stone, Graham N., Fuentes-Utrilla Pablo, Karsten Schönrogge, Pujade-Villar, Juli, Stone, GN, Pujade-Villar, J, Hayward, A, Nicholls, JA, Schönrogge, K, Melika, G, Tavakoli, M, Nieves-Aldrey, J-L, Csóka, G, Fuentes-Utrilla, P   +42 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Impact of carnivory on human development and evolution revealed by a new unifying model of weaning in mammals [PDF]

, 2012
Our large brain, long life span and high fertility are key elements of human evolutionary success and are often thought to have evolved in interplay with tool use, carnivory and hunting.
Psouni, Elia, Janke, Axel, Elia Psouni, Axel Janke, Psouni Elia, Elia Psouni (170421), Axel Janke (170425), Martin Garwicz (170429), Garwicz Martin, Janke Axel, Garwicz, Martin, Martin Garwicz, Garwicz, Martin,, Kristianstad University., Janke, Axel,, Lund University., Psouni, Elia,   +16 more
core   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Variation in seed dormancy quantitative trait loci in Arabidopsis thaliana originating from one site [PDF]

, 2011
A Quantitative Trait Locus (QTL) analysis was performed using two novel Recombinant Inbred Line (RIL) populations, derived from the progeny between two Arabidopsis thaliana genotypes collected at the same site in Kyoto (Japan) crossed with the reference ...
Reymond, M., Koornneef, M., Silady, R.A., Reymond Matthieu, Silady, R. A., Koornneef Maarten, Rebecca A Silady, Silady, R., Sigi Effgen, Maarten Koornneef, Effgen Sigi, Matthieu Reymond, Silady Rebecca A., Rebecca A. Silady, Effgen, S.   +14 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The age and evolution of an antiviral resistance mutation in Drosophila melanogaster [PDF]

, 2007
What selective processes underlie the evolution of parasites and their hosts? Arms-race models propose that new host-resistance mutations or parasite counter-adaptations arise and sweep to fixation.
Obbard, Darren J, Haddrill, Penelope R, Kim, Kang-Wook, Obbard, Darren J.; id_orcid, Haddrill, Penelope R., Bangham, Jenny, Jiggins, Francis M, Jiggins, Francis M.   +7 more
core   +1 more source