Results 51 to 60 of about 75,976 (219)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The limits of mean-field heterozygosity estimates under spatial extension in simulated plant populations [PDF]

, 2012
Computational models of evolutionary processes are increasingly required to incorporate multiple and diverse sources of data. A popular feature to include in population genetics models is spatial extension, which reflects more accurately natural ...
Kitchen, James, Allaby, Robin G., Robin G Allaby, James L Kitchen   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Distinct migratory and non-migratory ecotypes of an endemic New Zealand eleotrid (Gobiomorphus cotidianus) – implications for incipient speciation in island freshwater fish species [PDF]

, 2008
Background: Many postglacial lakes contain fish species with distinct ecomorphs. Similar evolutionary scenarios might be acting on evolutionarily young fish communities in lakes of remote islands.
Stoelting, K.N., Kai N Stölting, van den Heuvel, Michael, Clarke, Andrew C, Stevens, M.I., van den Heuvel, M.R., Brendan J Hicks, Meyer, Axel, Clarke, A.C., Stölting, Kai N, Hicks, Brendan J., Ray Tana, Stolting, Kai, Clarke, Andrew, Meyer, A., Tana, Raymond, Christian Michel, Heuvel, Michael R. van den, Tana, Ray, Michel, C., St�lting, Kai N, Hicks, B.J., Andrew C Clarke, Stevens, Mark I, van den Heuvel, Michael R, Mark I Stevens, Clarke, Andrew C., Hicks, Brendan, Tana, R., van den Heuvel, Michael R., Stevens, Mark Ian, Axel Meyer, Michael R van den Heuvel, Stevens, Mark I., Stölting, Kai N., Michel, Christian, Hicks, Brendan J   +36 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The effect of polyploidy and hybridization on the evolution of floral colour in Nicotiana (Solanaceae). [PDF]

, 2015
Speciation in angiosperms can be accompanied by changes in floral colour that may influence pollinator preference and reproductive isolation. This study investigates whether changes in floral colour can accompany polyploid and homoploid hybridization ...
Taylor, L, Arnold, Sarah E., Arnold, SE, Arnold, Sarah E. J., Chittka, Lars, Chittka, L, Kovařík, A, Le Comber, S., Knapp, S., Baldwin, Ian, Mhiri, C, Verity, Robert, Verity, R, Le Comber, SC, Taylor, Lin, Kelly, L., Le Comber, Steven C., Knapp, Sandra, Knapp, S, Leitch, A.R., Arnold, SEJ, Baldwin, I., Chase, M.W., Chittka, L., Leitch, AR, Leitch, Andrew R., Arnold, Sarah E.J., Mhiri, Corinne, McCarthy, E.W., Chase, Mark W., Kelly, LJ, Taylor, L., Arnold, S.E.J., Chase, M., Kovařík, Aleš, Kovařík, A., McCarthy, E., Leitch, A., Verity, R., McCarthy, Elizabeth W., Dodsworth, Steven, Kelly, L.J., Kelly, Laura J., Dodsworth, S., Mhiri, C., Dodsworth, S, Chase, MW, Arnold, S., Baldwin, I.T., Baldwin, Ian T., Le Comber, S.C., Baldwin, IT, McCarthy, EW   +52 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The mutational meltdown in asexual populations [PDF]

, 1993
Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of
Lynch, M., Bürger, R., Lynch, Michael, Butcher, D., Gabriel, W., Bürger, Reinhard, Gabriel, Wilfried   +6 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source