Results 41 to 50 of about 3,561 (165)

Evolution of the leukotoxin promoter in genus Mannheimia [PDF]

, 2009
<b>Background</b>: The <i>Mannheimia</i> species encompass a wide variety of bacterial lifestyles, including opportunistic pathogens and commensals of the ruminant respiratory tract, commensals of the ovine rumen, and pathogens of
Pedersen, A.G., Robert L Davies, Jesper Larsen, Kuhnert, Peter, Davies, Robert L, Olsen, John E, Pedersen Anders G, Bisgaard, M., Olsen, J., Olsen, John Elmerdahl, Frey, Joachim, Frey, J., Christensen, H., Pedersen, A., Kuhnert, P., Pedersen, Anders Gorm, Anders G Pedersen, Joachim Frey, Larsen, Jesper, Bisgaard, Magne, Christensen Henrik, Peter Kuhnert, Olsen, J.E., Christensen, Henrik, Bisgaard Magne, Davies, Robert L., Magne Bisgaard, Davies, R.L., John E Olsen, Kuhnert Peter, Olsen John E, Larsen Jesper, Frey Joachim, Larsen, J., Davies Robert L, Henrik Christensen   +35 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Adaptive and demographic responses of plankton populations to environmental change [PDF]

, 1991
Because of their large population sizes, short generation times, and clonal mode of propagation, microorganisms should often be the first members of a community to respond evolutionarily to temporal changes in the environment.
Lynch, Michael, Michael Lynch, A. Michelle Wood, Wood, A. M., Gabriel, Wilfried, Wilfred Gabriel   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Performance of generalist and specialist herbivores and their endoparasitoids differs on cultivated and wild Brassica populations [PDF]

, 2008
Through artificial selection, domesticated plants often contain modified levels of primary and secondary metabolites compared to their wild progenitors.
Harvey, Jeffrey A., Marcel Dicke, Dicke, M., James M. Bullock, Jeffrey A. Harvey, Van Dam, N.M., Dicke, Marcel, Bullock, James M., Gols, R., van Dam, Nicole, Bukovinszky, Tibor, Dam, N.M. van, Nicole M. van Dam, Tibor Bukovinszky, Gols, Rieta, Harvey, J.A., Gols, G.J.Z., Bullock, J.M., Rieta Gols, Bukovinszky, T., Dam, N.M., van   +20 more
core   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

First Steps towards Underdominant Genetic Transformation of Insect Populations [PDF]

, 2014
The idea of introducing genetic modifications into wild populations of insects to stop them from spreading diseases is more than 40 years old. Synthetic disease refractory genes have been successfully generated for mosquito vectors of dengue fever and ...
Reeves R. Guy, Philipp M. Altrock (340203), Jarosław Bryk, R Guy Reeves, Altrock, P., Jai A. Denton (185794), Jarosław Bryk (47108), Jai A Denton, Bryk, J., R. Guy Reeves (185792), Philipp M Altrock, Bryk, Jarek, Denton Jai A., Reed, F., Denton, Jai A., Floyd A Reed, Floyd A. Reed (185797), Altrock Philipp M., Reed, Floyd A., Altrock, Philipp M., Reeves, R. Guy, Bryk Jarosław, Reed Floyd A., Reeves, R., Denton, J.   +24 more
core   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Selection and evolution of causally covarying traits [PDF]

, 2014
The collection of the Soay sheep data is supported by the National Trust for Scotland and QinetQ, with funding from NERC, the Royal Society, and the Leverhulme Trust.When traits cause variation in fitness, the distribution of phenotype, weighted by ...
Morrissey, Michael Blair
core   +1 more source