Results 41 to 50 of about 75,976 (219)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring the Status of Population Genetics: The Role of Ecology [PDF]

, 2012
The status of population genetics has become hotly debated among biologists and philosophers of biology. Many seem to view population genetics as relatively unchanged since the Modern Synthesis and have argued that subjects such as development were left ...
Millstein, Roberta L.
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Genetic management strategies for controlling infectious diseases in livestock populations [PDF]

, 2003
This paper considers the use of disease resistance genes to control the transmission of infection through an animal population. Transmission is summarised by R0, the basic reproductive ratio of a pathogen.
Stephen C Bishop, Katrin M. MacKenzie, Bishop, SC, Bishop Stephen C, Stephen C. Bishop, Bishop, Stephen, MacKenzie, KA, MacKenzie Katrin M, Katrin M MacKenzie, Mackenzie, Katrin   +9 more
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Selection and evolution of causally covarying traits

, 2014
The collection of the Soay sheep data is supported by the National Trust for Scotland and QinetQ, with funding from NERC, the Royal Society, and the Leverhulme Trust.When traits cause variation in fitness, the distribution of phenotype, weighted by ...
Morrissey, Michael Blair
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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptation to a seasonally varying environment: a strong latitudinal cline in reproductive diapause combined with high gene flow in Drosophila montana

, 2011
Adaptation to seasonal changes in the northern hemisphere includes an ability to predict the forthcoming cold season from gradual changes in environmental cues early enough to prepare for the harsh winter conditions. The magnitude and speed of changes in
Knott, Emily, Salminen, Tiina S., Maaria Kankare, Venera I. Tyukmaeva, Salminen, Tiina, Knott, K Emily, Hoikkala, Anneli, K. Emily Knott, Anneli Hoikkala, Kankare, Maaria, Tyukmaeva, Venera, Tiina S. Salminen   +11 more
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Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle [PDF]

, 2015
Background Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus.
Magee, DA, Murphy, A., Lohan, AJ, Braud, Martin, Rue-Albrecht, K, Edwards, C.J., Schroeder, Steven, Park, S.D.E., Teasdale, Matthew D., McGettigan, Paul A., Mark, Donoghue, Braud, M, Murphy, Alison, Chamberlain, AT, Bradley, D.G., Chamberlain, Andrew, Liu, Yuan, McGettigan, PA, Lohan, A.J., Spillane, C, Magee, David A., Sonstegard, Tad S., Tai, S, Liu, Y, MacHugh, DE, Murphy, A, School of Earth and Environmental Sciences, Schroeder, S, Tai, Shuaishuai, Bradley, Daniel G., Spillane, Charles, Donaghue, M.T., Park, SD, Braud, M., Loftus, Brendan J., Park, Stephen D E, Chamberlain, Andrew T., Loftus, BJ, MacHugh, David E., Park, Stephen D. E., Bradley, DG, Donoghue, Mark T., Lohan, Amanda J., Teasdale, M.D., Liu, Y., McGettigan, P.A., Teasdale, MD, Magee, D.A., Sonstegard, TS, Donoghue, MT, Edwards, CJ, University of Dublin Trinity College, Rue-Albrecht, Kévin, Chamberlain, A.T., Edwards, Ceiridwen J.   +54 more
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Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Evolution of Altruism in Spatially Structured Populations [PDF]

The evolution of altruism in humans is still an unresolved puzzle. Helping other individuals is often kinship-based or reciprocal. Several examples show, however, that altruism goes beyond kinship and reciprocity and people are willing to support ...
Andr�s N�meth, K�roly Tak�cs
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