Results 51 to 60 of about 2,938,755 (230)

20 questions on Adaptive Dynamics [PDF]

, 2005
Adaptive Dynamics is an approach to studying evolutionary change when fitness is density or frequency dependent. Modern papers identifying themselves as using this approach first appeared in the 1990s, and have greatly increased up to the present ...
Abrams, Abrams, Abrams, Altenberg, Arnold, Asmussen, Asmussen, Avise, Barton, Bolnick, Bulmer, Bulmer, Bürger, Bürger, Caisse, Christiansen, Christiansen, Cockerham, Crosby, Crow, Crow, D. WAXMAN, Dickinson, Dieckmann, Dieckmann, Diehl, Doebeli, Dooren, Dooren, Doorn, Doorn, Endler, Eshel, Eshel, Fear, Felsenstein, Fisher, Gavrilets, Gavrilets, Gavrilets, Gavrilets, Geritz, Geritz, Geritz, Ginzburg, Haldane, Hofbauer, Kimura, Kingman, Kisdi, Kostitzin, Lande, Lewontin, Ludwig, Marks, Matessi, Matessi, Matsuda, Maynard Smith, Metz, Metz, Mizera, Moore, Moore, Mylius, Nowak, Orr, Orr, Provine, Provine, Reed, Rice, Roughgarden, Roughgarden, S. GAVRILETS, Schaffer, Slatkin, Slatkin, Slatkin, Spencer, Spencer, Taylor, Tienderen, Turelli, Udovic, Vincent, Waxman, Welch, Wilson, Wright, Wright, Zeng   +91 more
core   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Fluctuation Domains in Adaptive Evolution

, 2010
We derive an expression for the variation between parallel trajectories in phenotypic evolution, extending the well known result that predicts the mean evolutionary path in adaptive dynamics or quantitative genetics.
Abrams, Carl Boettiger, Champagnat, Champagnat, Champagnat, Chevin, Cooper, Dieckmann, Dieckmann, Duffy, Feller, Gentleman, Geritz, Geritz, Geritz, Geritz, Gillespie, Hofbauer, Jonathan Dushoff, Joshua S. Weitz, Kimura, Kimura, Kurtz, Lande, Lande, Levins, Levins, Nowak, Ohta, Olsen, Rueffler, Schwab, Stodden, van Kampen, Wichman, Wright, Wright   +36 more
core   +1 more source

Bifurcations of self-similar solutions of the Fokker-Plank Equation [PDF]

arXiv, 2006
A class of one-dimensional Fokker-Plank equations having a common stationary solution, which is a power function of the state of the process, was found. We prove that these equations also have generalized self-similar solutions which describe the temporary transition from one stationary state to another.
arxiv  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Understanding the evolution of native pinewoods in Scotland will benefit their future management and conservation [PDF]

, 2010
Scots pine (Pinus sylvestris L.) is a foundation species in Scottish highland forests and a national icon. Due to heavy exploitation, the current native pinewood coverage represents a small fraction of the postglacial maximum.
Barton, Davis, FORREST, FORREST, G. R. Iason, Gonzalez-Martinez, J. E. Cottrell, Johnsen, M. J. Salmela, Magri, Naydenov, Neale, PERKS, Provan, R. A. Ennos, Robledo-Arnuncio, Robledo-Arnuncio, S. Cavers, Slatkin, Soranzo, Sork, W. Wachowiak, Yeaman   +22 more
core   +1 more source

High-Throughput Biologically Optimized Search Engineering Approach to Synthetic Biology [PDF]

arXiv, 2011
Synthetic Biology is the new engineering-based approach to biology that includes applications of designing complex biological devices. At present, it is not yet clear what will emerge as the defining principles of Synthetic Biology. One proposed approach is to build Synthetic Biology around the classical engineering principles of standardization ...
arxiv  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Mathematics at the eve of a historic transition in biology [PDF]

arXiv, 2017
A century ago physicists and mathematicians worked in tandem and established quantum mechanism. Indeed, algebras, partial differential equations, group theory, and functional analysis underpin the foundation of quantum mechanism. Currently, biology is undergoing a historic transition from qualitative, phenomenological and descriptive to quantitative ...
arxiv  

Oxygen Channels and Fractal Wave-Particle Duality in the Evolution of Myoglobin and Neuroglobin [PDF]

, 2016
The evolution of terrestrial and aquatic wild type (WT) globins is dominated by changes in two proximate - distal Histidine ligand exit channels, here monitored quantitatively by hydropathic waves. These waves reveal allometric functional features inaccessible to single amino acid stereochemical contact models, and even very large all-atom Newtonian ...
arxiv   +1 more source