Results 51 to 60 of about 380,874 (247)

20 questions on Adaptive Dynamics [PDF]

, 2005
Adaptive Dynamics is an approach to studying evolutionary change when fitness is density or frequency dependent. Modern papers identifying themselves as using this approach first appeared in the 1990s, and have greatly increased up to the present ...
Abrams, Abrams, Abrams, Altenberg, Arnold, Asmussen, Asmussen, Avise, Barton, Bolnick, Bulmer, Bulmer, Bürger, Bürger, Caisse, Christiansen, Christiansen, Cockerham, Crosby, Crow, Crow, D. WAXMAN, Dickinson, Dieckmann, Dieckmann, Diehl, Doebeli, Dooren, Dooren, Doorn, Doorn, Endler, Eshel, Eshel, Fear, Felsenstein, Fisher, Gavrilets, Gavrilets, Gavrilets, Gavrilets, Geritz, Geritz, Geritz, Ginzburg, Haldane, Hofbauer, Kimura, Kingman, Kisdi, Kostitzin, Lande, Lewontin, Ludwig, Marks, Matessi, Matessi, Matsuda, Maynard Smith, Metz, Metz, Mizera, Moore, Moore, Mylius, Nowak, Orr, Orr, Provine, Provine, Reed, Rice, Roughgarden, Roughgarden, S. GAVRILETS, Schaffer, Slatkin, Slatkin, Slatkin, Spencer, Spencer, Taylor, Tienderen, Turelli, Udovic, Vincent, Waxman, Welch, Wilson, Wright, Wright, Zeng   +91 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Universal expressions of population change by the Price equation: natural selection, information, and maximum entropy production

, 2017
The Price equation shows the unity between the fundamental expressions of change in biology, in information and entropy descriptions of populations, and in aspects of thermodynamics.
Frank, Steven A.
core   +1 more source

Cooperation, Norms, and Revolutions: A Unified Game-Theoretical Approach [PDF]

, 2010
Cooperation is of utmost importance to society as a whole, but is often challenged by individual self-interests. While game theory has studied this problem extensively, there is little work on interactions within and across groups with different ...
A Baronchelli, A Blume, A Flache, A Lindbeck, A Traulsen, Anders Johansson, AS Griffin, B Skyrms, B Skyrms, C Bicchieri, C Castelfranchi, C Horne, C Horne, C Horne, C Taylor, CP Roca, D Centola, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, DD Heckathorn, Dirk Helbing, E Ben Jacob, E Fehr, E Fehr, E Fehr, E Fehr, E Fehr, E Ostrom, E Ostrom, E Posner, E Ullmann-Margalit, E Van Damme, EC Banfield, EC Zeeman, Enrico Scalas, EO Wilson, F Dignum, F Flentge, FACC Chalub, G Szabó, GC Homans, H Gintis, H Gintis, H Ohtsuki, H Popitz, HP Young, I Bohnet, J Bendor, J Bendor, J Elster, J Elster, J Henrich, J Hofbauer, J Hofbauer, J Kitts, J-P Platteau, JA Fletcher, JC Harsanyi, JM Epstein, JM Galan, JS Coleman, JW Weibull, K Binmore, K Binmore, K Keizer, K-D Opp, K-D Opp, K-D Opp, K-D Opp, KH Schlag, KJ Koford, L Lehmann, L Samuelson, M Bacharach, M Bacharach, M Bacharach, M Kandori, M Milinski, M Moussaïd, M Nakamaru, M Neumann, MA Nowak, MA Nowak, MA Nowak, MW Macy, MW Macy, N Saam, O Thébaud, P David, P Oliver, P Schuster, PR Ehrlich, R Axelrod, R Axelrod, R Boyd, R Boyd, R Boyd, R Boyd, R Conte, R Conte, R Cressman, R Cressman, R Cressman, R Cressman, R Cressman, R Ellickson, R Sethi, R Sugden, R Sugden, R Sugden, R Sugden, RA Posner, RB Cialdini, RC Ellickson, RD Putnam, S Diederich, S Macaulay, SA Stouffer, T Bonner, T Clutton-Brock, T Fent, T Galla, T Kanazawa, T Voss, TS Kuhn, V Buskens, VM de Oliveria, VM de Oliveria, W Raub, W Weidlich, WB Arthur, X Castello, Y Sato   +138 more
core   +7 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Estimators for QST and coalescence times. [PDF]

, 2016
Comparisons of QST to FST can provide insights into the evolutionary processes that lead to differentiation, or lack thereof, among the phenotypes of different groups (e.g., populations, species), and these comparisons have been performed on a variety of
Weaver, Timothy D
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Measuring vertebrate telomeres: applications and limitations [PDF]

, 2004
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity.
Allsopp RC, Barja G, Benetos A, Broccoli D, Chang E, Charnov E, Friedrich U, Gemmell NJ, Girondot M, Grant JD, Harley CB, IUCN, Jeanclos E, Kern S, Lambertsen RH, Meyne J, Miyashita N, Ogburn CE, Olsen E, Prowse KR, Rose MR, Slagboom PE, Stearns SC, Stearns SC, Turker M, Vaziri H, Watson J, Zeichner SL   +27 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source