Results 61 to 70 of about 377,168 (131)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Stochastic delocalization of finite populations

, 2012
Heterogeneities in environmental conditions often induce corresponding heterogeneities in the distribution of species. In the extreme case of a localized patch of increased growth rates, reproducing populations can become strongly concentrated at the ...
Kimura M, Kimura M, Kolmogorov A N, Lukas Geyrhofer, Lynch M, Oskar Hallatschek, Tunnicliffe V, Whitlock M C, Wolff A   +8 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Law of Nature?

, 2011
Is there an overriding principle of nature, hitherto overlooked, that governs all population behavior? A single principle that drives all the regimes observed in nature - exponential-like growth, saturated growth, population decline, population ...
Chester, Marvin
core   +1 more source

Adaptive evolution of molecular phenotypes

, 2014
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad, Chernyak V Y, Crow J F, Falconer D S, Fisher R, Lynch M, Lynch M, Lynch M, Michael Lässig, Muller H J, Neher R A, Nourmohammad A, Nourmohammad A, Torsten Held   +13 more
core   +1 more source

Steps towards operationalizing an evolutionary archaeological definition of culture [PDF]

, 2011
This paper will examine the definition of archaeological cultures/techno-complexes from an evolutionary perspective, in which culture is defined as a system of social information transmission.
Riede, F
core  

Integrated phenotypes:understanding trait covariation in plants and animals [PDF]

, 2014
Armbruster, Scott, Bolstad, Geir H., Hansen, Thomas F., Pelabon, Christophe   +3 more
core   +1 more source

Genetic constraints predict evolutionary divergence in Dalechampia blossoms [PDF]

, 2014
Armbruster, Scott, Bolstad, Geir H., Falahati-Anbaran, Mohsen, Hansen, Thomas F., Pelabon, Christophe, Perez-Barrales, Rocio   +5 more
core   +1 more source

Bridging developmental and statistical approaches to variation and evolution. [PDF]

Proc Natl Acad Sci U S A
Milocco L, Uller T.
europepmc   +1 more source