Results 61 to 70 of about 380,874 (247)
, 2011 Is there an overriding principle of nature, hitherto overlooked, that governs all population behavior? A single principle that drives all the regimes observed in nature - exponential-like growth, saturated growth, population decline, population ...
Chester, Marvin
core +1 more source
A benign juvenile environment reduces the strength of antagonistic pleiotropy and genetic variation in the rate of senescence [PDF]
, 2015 The environment can play an important role in the evolution of senescence because the optimal allocation between somatic maintenance and reproduction depends on external factors influencing life expectancy.
Gonzalez G. +3 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Stochastic delocalization of finite populations
, 2012 Heterogeneities in environmental conditions often induce corresponding heterogeneities in the distribution of species. In the extreme case of a localized patch of increased growth rates, reproducing populations can become strongly concentrated at the ...
Kimura M +8 more
core +1 more source
Ecological and Genetic Barriers Differentiate Natural Populations of Saccharomyces cerevisiae
Molecular biology and evolution, 2015 How populations that inhabit the same geographical area become genetically differentiated is not clear. To investigate this, we characterized phenotypic and genetic differences between two populations of Saccharomyces cerevisiae that in some cases ...
Katie J. Clowers +4 more
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Understanding local adaptation in a freshwater salmonid fish: evolution of a research programme
ICES Journal of Marine Science, 2019 Linking ecology and evolution can be challenging, particularly as these fields evolve rapidly tracking technological and theoretical developments.
L. A. Vøllestad, C. Primmer
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Evolution Is a Quantitative Science
PLoS Biology, 2010 Evolutionary genetics is a mature field of endeavour, and some of biology’s greatest minds have contributed to the theory of population genetics. Initially, they faced a problem, in that following the rediscovery of Mendel’s results in the early years of
J. Brookfield
semanticscholar +1 more source