Results 51 to 60 of about 3,681,793 (314)
Measuring democracy among ordinary citizens—Challenges to studying democratic ideals
Frontiers in Political Science, 2022 The article addresses the methodological challenges in measuring democratic ideals on an individual level in quantitative studies. Building upon own empirical research, the study identifies several difficulties in assessing individuals' attitudes on ...
Jan-Erik Refle
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Quantitative Longitudinal Data Analysis
, 2020 First published Open Access under a Creative Commons license as What is Quantitative Longitudinal Data Analysis?, this title is now also available as part of the Bloomsbury Research Methods series.
Lambert, Paul, Gayle, Vernon
core
Centroidous Method for Determining Objective Weights
MathematicsWhen using multi-criteria decision-making methods in applied problems, an important aspect is the determination of the criteria weights. These weights represent the degree of each criterion’s importance in a certain group.
Irina Vinogradova-Zinkevič
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Navigating the paradigm shift of sex inclusive preclinical research and lessons learnt
Communications BiologyAfter thirty years of research highlighting the risk of the sex bias in preclinical research, we now have tangible change happening in the research landscape with a rapid increase in the proportions of studies including female and male subjects.
Natasha A. Karp
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BepiTBR: T-B reciprocity enhances B cell epitope prediction
iScience, 2022 Summary: The ability to predict B cell epitopes is critical for biomedical research and many clinical applications. Investigators have observed the phenomenon of T-B reciprocity, in which candidate B cell epitopes with nearby CD4+ T cell epitopes have ...
James Zhu +5 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
A new chapter for RCSB Protein Data Bank Molecule of the Month in 2025
Structural DynamicsThe online Molecule of the Month series authored by David S. Goodsell and published by the Research Collaboratory for Structural Biology Protein Data Bank at PDB101.RCSB.org has highlighted stories about the biomolecular structures driving fundamental ...
Janet Iwasa +3 more
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Dynamic Mixed Data Analysis and Visualization
Entropy, 2022 One of the consequences of the big data revolution is that data are more heterogeneous than ever. A new challenge appears when mixed-type data sets evolve over time and we are interested in the comparison among individuals. In this work, we propose a new
Aurea Grané +2 more
doaj +1 more source