Results 131 to 140 of about 1,352,768 (318)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Evaluation of Waveform Mapping as a Signal Processing Tool for Quantitative Ultrasonic NDE

, 1993
The mapping of one pulsed waveform into another, more desirable waveform by the application of a time-domain filter has been employed in a number of NDE situations.
Johnston, Patrick H., Patrick H. Johnston, Kishoni, Doron, Johnston, Patrick, Doron Kishoni   +4 more
core   +1 more source

Developing success criteria model, quantitative evaluation method, and process framework for building projects

Cogent Engineering
The construction industry faces challenges in evaluating success due to inconsistent methods and a lack of uniformity. Traditional evaluation methods often result in subjective and biased results.
Goshu Gebremikal Beshah, Wubishet Jekale Mengesha, Belachew Astrey Demiss   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Quantitative Evaluation of Steel Corrosion in Microenvironments Using the Corrosion Coulometer

, 1992
A corrosion sensor, termed a corrosion coulometer, has been developed for use on steel structures. The corrosion coulometer quantifies the corrosion occurring on a steel element due to atmospheric conditions such as dust, debris, humidity, condensation ...
Michalerya, William, William D. Michalerya, Granata, Richard, O'Malley, Brendan, Roger H. Wildt, Richard D. Granata, Wildt, Roger, Henry Leidheiser, Brendan W. O’Malley, Leidheiser, Henry   +9 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Quantitative Computerized Laminography

, 1989
Industrial computerized-tomography (CT) systems have been used to perform visual and quantitative analysis on industrial objects for several years. A tomogram is formed by placing an object between a radiation source and an arc of detectors, and rotating
Buchele, Suzanne, Ellinger, Hunter, Hunter Ellinger, Suzanne Fox Buchele   +3 more
core   +1 more source

In situ evaluation and manipulation of lithium plating morphology enabling safe and long‐life lithium‐ion batteries

InfoMat
The morphology of plated lithium (MPL) metal on graphite anodes, traditionally described as “moss‐like” and “dendrite‐like”, exert a substantial negative influence on the performance of lithium‐ion batteries (LIBs) by modulating the metal‐electrolyte ...
Shuoyuan Mao, Yu Wang, Yao Lu, Xuebing Han, Yuejiu Zheng, Xuning Feng, Xinqi Ren, Languang Lu, Minggao Ouyang   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source