Results 141 to 150 of about 1,352,768 (318)

Quantitative Nondestructive Evaluation of Adhesive Bond Strength

, 1988
Performance determination of adhesively bonded systems is a subject of intense interest to both researchers and designers. Attempts to predict adhesive bond performance have mainly focused on nondestructively identifying gross anomalies such as voids or ...
Leroy R. Hause, Gosse, Jonathan, Jonathan H. Gosse, Hause, Leroy   +3 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Research on Adaptive Reuse Strategy of Industrial Heritage Based on the Method of Social Network

Land
With the deceleration of urban expansion, the adaptive reuse of industrial heritage buildings has emerged as a novel area of research. In previous times, the majority of approaches to adapting industrial heritage buildings relied on experiential ...
Jinghua Song, Junyang Chen, Xiu Yang, Yuyi Zhu   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Computational Fluid Dynamics Study on Bottom-Hole Multiphase Flow Fields Formed by Polycrystalline Diamond Compact Drill Bits in Foam Drilling

Fluids
High-temperature geothermal wells frequently employ foam drilling fluids and Polycrystalline Diamond Compact (PDC) drill bits. Understanding the bottom-hole flow field of PDC drill bits in foam drilling is essential for accurately analyzing their ...
Lihong Wei, Jaime Honra
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Quantitative NDE Using Imagery and Other Known Information about a Test Object

, 1990
Nondestructive Evaluation (NDE) often requires learning about the state of the interior or surface of a test object without direct observation. Traditionally this has been done with limited means, often by applying simple acoustic, electromagnetic or ...
Warren G. Heller, Heller, Warren
core   +1 more source

Analysis of Universal Decoding Techniques for 6G Ultra-Reliable and Low-Latency Communication Scenario

Future Internet
Ultra-reliable and low-latency communication (URLLC) in 6G networks is characterized by very high reliability and very low latency to enable mission-critical applications.
Abhilasha Gautam, Prabhat Thakur, Ghanshyam Singh   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Inversion-based workflow for oilfield nested multicasing evaluation using electromagnetic low-frequency measurements

, 2016
Steel casing corrosion analysis is pivotal in well integrity evaluation for ensuring environment-friendly and efficient hydrocarbon production and for well abandonment at the end of the productive life of the well.
Omar, Saad, Saad Omar, Omeragic, Dzevat, Dzevat Omeragic   +3 more
core   +1 more source