Results 31 to 40 of about 31,502 (199)

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi   +4 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Improvement of maintenance visibility analysis method based on human visual field cone

open access: yesZhongguo Jianchuan Yanjiu, 2020
Objectives Since the visual cone maintenance visibility analysis method based on the visual field of the human eye cannot quantitatively evaluate visibility and visual field occlusion, an improved visibility evaluation model is proposed.Methods First ...
HE Chunhua   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Use of line laser scanning thermography for the defect detection and evaluation of composite material

open access: yesScience and Engineering of Composite Materials, 2022
The line laser scanning thermography was applied for the defect detection and evaluation of composite material in this work, which was carried out by the following procedures.
Li Yin   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Adaptation and Psychometric Validation of the Spanish Version of Two Measures of Agentic Engagement

open access: yesBehavioral Sciences
This study focuses on the adaptation and psychometric validation of the Spanish versions of the Agentic Engagement Scale (AES) and the Enlarged Version of the Agentic Engagement Scale (EVAES) in Spanish undergraduate students.
Estefania Guerrero   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

open access: yesClinical and Translational Science
Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to ...
Robert Hopefl   +6 more
doaj   +1 more source

Enhancing patient-reported outcomes in stroke care: a path to improved well-being

open access: yesFrontiers in Neurology
Patient-reported outcomes (PROs) present a valuable opportunity to enhance stroke care by capturing symptoms and experiences often missed by traditional outcome measures like the modified Rankin Scale.
Irene L. Katzan   +7 more
doaj   +1 more source

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