Results 51 to 60 of about 3,675,358 (282)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Clinical and Translational ScienceRare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to ...
Robert Hopefl +6 more
doaj +1 more source
Enhancing patient-reported outcomes in stroke care: a path to improved well-being
Frontiers in NeurologyPatient-reported outcomes (PROs) present a valuable opportunity to enhance stroke care by capturing symptoms and experiences often missed by traditional outcome measures like the modified Rankin Scale.
Irene L. Katzan +7 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The meaning of some common terms used in sampling toxic phytoplankton [PDF]
, 1994 The author explains some aspects of sampling phytoplankton blooms and the evaluation of results obtained from different methods.
Lindholm, Tore
core
A Quantitative Evaluation of the Galaxy Component of COSMOS and APM Catalogs [PDF]
, 1999 We have carried out an independent quantitative evaluation of the galaxy component of the "COSMOS/UKST Southern Sky Object Catalogue" (SSC) and the "APM/UKST J Catalogue" (APM).
Beard S. M. +17 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A Review of Theory and Practice in Scientometrics [PDF]
, 2015 Scientometrics is the study of the quantitative aspects of the process of science as a communication system. It is centrally, but not only, concerned with the analysis of citations in the academic literature.
Leydesdorff, Loet, Mingers, John
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Education Maintenance Allowance : the first two years : a quantitative evaluation [PDF]
, 2002 The Department for Education and Skills (DfES) has commissioned a longitudinal evaluation of the piloting of Education Maintenance Allowances (EMAs).
Ashworth, Karl +9 more
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