Results 141 to 150 of about 391,632 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Quantitative Genetics [PDF]

Evolution, 1999
Trudy F. C. Mackay, Michael Lynch, Bruce Walsh   +2 more
openaire   +2 more sources

Toward an Information Theory of Quantitative Genetics. [PDF]

J Comput Biol, 2021
Galas DJ, Kunert-Graf J, Uechi L, Sakhanenko NA.   +3 more
europepmc   +1 more source

Quantitative genetics in conservation biology

Genetical Research, 1999
Most of the major genetic concerns in conservation biology, including inbreeding depression, loss of evolutionary potential, genetic adaptation to captivity and outbreeding depression, involve quantitative genetics. Small population size leads to inbreeding and loss of genetic diversity and so increases extinction risk.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rate of double reduction and genetic variability in yield, quality, and senescence related traits in tetraploid potato (Solanum tuberosum L.)

Frontiers in Plant Science
The amount of genetic variability is the foundation for genetic change in any plant breeding program, and the amount of double reduction can influence genetic gain and the amount of future genetic diversity in polyploid species.
Muhammad Farhan Yousaf, Muhammad Farhan Yousaf, Vipin Tomar, Hélène Romé, Merethe Bagge, Mathias Timmermann, Thinh Tuan Chu, Just Jensen   +7 more
doaj   +1 more source

Conceptualizing the evolutionary quantitative genetics of phenological life-history events: Breeding time as a plastic threshold trait. [PDF]

Evol Lett, 2022
Reid JM, Acker P.
europepmc   +1 more source

Crop growth models for the -omics era: the EU-SPICY project

, 2010
The prediction of phenotypic responses from genetic and environmental information is an area of active research in genetics, physiology and statistics.
Heuvelink, E., Glasbey, C., Magán, J., Palloix, A., Heijden, G.W.A.M., van der, Dieleman, J.A., Barócsi, A., Voorrips, R.E., Bink, M.C.A.M., Vuylsteke, M., Eeuwijk, F.A., van   +10 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source