Results 131 to 140 of about 851,465 (291)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A comparative analysis of agronomic water-use efficiency and its proxy measures as derived from key morpho-physiological and supportive quantitative genetics attributes of perennial ryegrass under imposed drought. [PDF]

Plant Environ Interact, 2023
Weerarathne LVY, Jahufer Z, Schäufele R, Lopez I, Matthew C.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Quantitative Genetics [PDF]

Evolution, 1999
Trudy F. C. Mackay, Michael Lynch, Bruce Walsh   +2 more
openaire   +2 more sources

Rate of double reduction and genetic variability in yield, quality, and senescence related traits in tetraploid potato (Solanum tuberosum L.)

Frontiers in Plant Science
The amount of genetic variability is the foundation for genetic change in any plant breeding program, and the amount of double reduction can influence genetic gain and the amount of future genetic diversity in polyploid species.
Muhammad Farhan Yousaf, Muhammad Farhan Yousaf, Vipin Tomar, Hélène Romé, Merethe Bagge, Mathias Timmermann, Thinh Tuan Chu, Just Jensen   +7 more
doaj   +1 more source

Conceptualizing the evolutionary quantitative genetics of phenological life-history events: Breeding time as a plastic threshold trait. [PDF]

Evol Lett, 2022
Reid JM, Acker P.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Restoring fertility in yeast hybrids: Breeding and quantitative genetics of beneficial traits. [PDF]

Proc Natl Acad Sci U S A, 2021
Naseeb S, Visinoni F, Hu Y, Hinks Roberts AJ, Maslowska A, Walsh T, Smart KA, Louis EJ, Delneri D.   +8 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source