Results 111 to 120 of about 391,632 (299)

ANTHROPOLOGICAL GENETICS: THEORY, METHODS AND APPLICATIONS

, 2007
List of contributors -- Preface -- Ch. 1. Foundations of anthropological genetics / M.H. Crawford -- Pt. I. Theory -- Ch. 2. Partitioning of genetic variation in human populations and the concept of race / Lorena Madrigal and Guido Barbujani -- Ch ...
Crawford, Michael H., ed.
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Quantitative genetics [PDF]

Nature, 2008
openaire   +3 more sources

Manual of Procedures In Quantitative Genetics

, 1967
xi.59 hal.;ill.; 24 ...
Walter A. Becker
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

ADAM-Plant: A Software for Stochastic Simulations of Plant Breeding From Molecular to Phenotypic Level and From Simple Selection to Complex Speed Breeding Programs

Frontiers in Plant Science, 2019
Making decisions on plant breeding programs require plant breeders to be able to test different breeding strategies by taking into account all the crucial factors affecting crop genetic improvement.
Huiming Liu, Biructawit Bekele Tessema, Just Jensen, Fabio Cericola, Jeppe Reitan Andersen, Anders Christian Sørensen   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The soil microbiome of Lolium perenne L. depends on host genotype, is modified by nitrogen level and varies across season

Scientific Reports
Genotype by environment interactions (G × E) are frequently observed in herbage production. Understanding the underlying biological mechanisms is important for achieving stable and predictive outputs across production environments.
Cristiana Paina, Mattia Fois, Torben Asp, Just Jensen, Pernille Bjarup Hansen, Palle Duun Rohde   +5 more
doaj   +1 more source

The integration of ‘omic’ disciplines and systems biology in cattle breeding

, 2010
peer-reviewedEnormous progress has been made in the selection of animals, including cattle, for specific traits using traditional quantitative genetics approaches.
Diskin, Michael G., M.G. Diskin, C.J. Creevey, D. Morris, Mullen, Michael P., D.P. Berry, S. Butler, Morris, Dermot G., M.P. Mullen, Meade, Kieran G, Butler, Stephen T., K.G. Meade, Creevey, Christopher J., Berry, Donagh   +13 more
core   +1 more source