Results 91 to 100 of about 391,632 (299)

Efficient QTL detection for nonhost resistance in wild lettuce: backcross inbred lines versus F2

, 2008
In plants, several population types [F2, recombinant inbred lines, backcross inbred lines (BILs), etc.] are used for quantitative trait locus (QTL) analyses.
Stam, P., M. J. W. Jeuken, P. Stam, Pelgrom, K.T.B., K. Pelgrom, Jeuken, M.J.W., Lindhout, P., P. Lindhout   +7 more
core   +1 more source

Spatially structured genetic variation in a broadcast spawning bivalve: quantitative vs. molecular traits [PDF]

, 2003
Understanding the origin, maintenance and significance of phenotypic variation is one of the central issues in evolutionary biology. An ongoing discussion focuses on the relative roles of isolation and selection as being at the heart of genetically based
Drent, J., Delden, W. van,, J. Drent, Piersma, T.,, Luttikhuizen, PC, Drent, J, Luttikhuizen, P.C., Piersma, T, Piersma, T.; id_orcid, Luttikhuizen, P.C.,, T. Piersma, van Delden, W, P. C. Luttikhuizen, Drent, J.,, Piersma, T., van Delden, W., W. Van Delden   +16 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Modeling heterogeneous (co)variances from adjacent-SNP groups improves genomic prediction for milk protein composition traits

Genetics Selection Evolution, 2017
Background Accurate genomic prediction requires a large reference population, which is problematic for traits that are expensive to measure. Traits related to milk protein composition are not routinely recorded due to costly procedures and are considered
Grum Gebreyesus, Mogens S. Lund, Bart Buitenhuis, Henk Bovenhuis, Nina A. Poulsen, Luc G. Janss   +5 more
doaj   +1 more source

Quantitative Genetics and Genomics of Drosophila Life Span

, 2006
Limited life span and senescence are near-universal characteristics of eukaryotic organisms, controlled by many interacting quantitative trait loci (QTLs) with individually small effects, whose expression is sensitive to the environment.
Wilson, Rhonda Henderson
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Use of genomic information to exploit genotype-by-environment interactions for body weight of broiler chicken in bio-secure and production environments

Genetics Selection Evolution, 2019
Background The increase in accuracy of prediction by using genomic information has been well-documented. However, benefits of the use of genomic information and methodology for genetic evaluations are missing when genotype-by-environment interactions (G ×
Thinh T. Chu, John W. M. Bastiaansen, Peer Berg, Hélène Romé, Danye Marois, John Henshall, Just Jensen   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Genetic parameters for social effects on survival in cannibalistic layers: Combining survival analysis and a linear animal model

, 2010
Background Mortality due to cannibalism in laying hens is a difficult trait to improve genetically, because censoring is high (animals still alive at the end of the testing period) and it may depend on both the individual itself and the behaviour of its ...
Veerkamp Roel F, Veerkamp, Roel F., Ducrocq, V.P., Ducrocq, Vincent, Bijma, Piter, Bijma Piter, Ducro, B.J., Esther D Ellen, Ellen, Esther D., Bijma, P., Ellen Esther D, Ellen, E.D., Veerkamp, Roel F, Roel F Veerkamp, Ducro, Bart J., Veerkamp, R.F., Vincent Ducrocq, Ducro Bart J, Bart J Ducro, Ducrocq Vincent, Ducro, Bart J, Piter Bijma   +21 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source