Results 81 to 90 of about 3,834,201 (338)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Efficient QTL detection for nonhost resistance in wild lettuce: backcross inbred lines versus F2 [PDF]

, 2008
In plants, several population types [F2, recombinant inbred lines, backcross inbred lines (BILs), etc.] are used for quantitative trait locus (QTL) analyses.
Stam, P., M. J. W. Jeuken, P. Stam, Pelgrom, K.T.B., K. Pelgrom, Jeuken, M.J.W., Lindhout, P., P. Lindhout   +7 more
core   +1 more source

Statistical model and testing designs to increase response to selection with constrained inbreeding in genomic breeding programs for pigs affected by social genetic effects

Genetics Selection Evolution, 2021
Background Social genetic effects (SGE) are the effects of the genotype of one animal on the phenotypes of other animals within a social group. Because SGE contribute to variation in economically important traits for pigs, the inclusion of SGE in ...
Thinh Tuan Chu, Mark Henryon, Just Jensen, Birgitte Ask, Ole Fredslund Christensen   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gene and QTL detection in a three-way barley cross under selection by a mixed model with kinship information using SNPs [PDF]

, 2011
Quantitative trait locus (QTL) detection is commonly performed by analysis of designed segregating populations derived from two inbred parental lines, where absence of selection, mutation and genetic drift is assumed.
Casas, Ana M., Ramsay, L., Fred A. van Eeuwijk, Mónica Elía, Bhat, Prasanna R., Malosetti, Marcos, Molina-Cano, José-Luis, Eeuwijk, F.A., van, Martin P. Boer, Luke Ramsay, van Eeuwijk, F.A., Molina-Cano, J.L., Elía, Mónica, Marian Moralejo, Ramsay, Luke, Boer, M., Eeuwijk, Fred A. van, Moralejo, Marian, Ramsay, Luke D., Ana M. Casas, Molina-Cano, José Luis, José-Luis Molina-Cano, Boer, Martin P., Moralejo, María Ángeles, Marcos Malosetti, Malosetti, M., Casas Cendoya, Ana María, Prasanna R. Bhat, Bhat, P., Casas, A., Elia, M., van Eeuwijk, Fred A.   +31 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

General resources in Genetics and/or Oncology [PDF]

, 2016
Review on General resources in Genetics and/or ...
Mossafa, Hossain, Huret, Jean-Loup, Dessen, Philippe, De Braekeleer, Etienne, Hautaviita, Katriina   +4 more
core   +3 more sources

Bias in estimates of variance components in populations undergoing genomic selection: a simulation study

BMC Genomics, 2019
Background After the extensive implementation of genomic selection (GS), the choice of the statistical model and data used to estimate variance components (VCs) remains unclear.
Hongding Gao, Per Madsen, Gert Pedersen Aamand, Jørn Rind Thomasen, Anders Christian Sørensen, Just Jensen   +5 more
doaj   +1 more source

Understanding the potential bias of variance components estimators when using genomic models

Genetics Selection Evolution, 2018
Background Genomic models that link phenotypes to dense genotype information are increasingly being used for infering variance parameters in genetics studies.
Beatriz C. D. Cuyabano, A. Christian Sørensen, Peter Sørensen   +2 more
doaj   +1 more source

Accurate recombination estimation from pooled genotyping and sequencing: a case study on barley

BMC Genomics, 2022
Sexual reproduction involves meiotic recombination and the creation of crossing over between homologous chromosomes, which leads to new allele combinations. We present a new approach that uses the allele frequency differences and the physical distance of
Michael Schneider, Federico Casale, Benjamin Stich   +2 more
doaj   +1 more source