Results 71 to 80 of about 391,632 (299)

An Introduction to Quantitative Genetics

open access: yes, 1999
This chapter provides a brief overview of quantitative-genetic theory. Quantitative-genetics provides important tools to help elucidate the genetic underpinnings of behavioral and neural phenotypes. This information can then provide substantial insights into the previous evolutionary history of a phenotype, as well as into brain-behavior relationships.
openaire   +2 more sources

THE QUANTITATIVE GENETICS OF FLUCTUATING ASYMMETRY [PDF]

open access: yesEvolution, 2001
Uploaded by Plazi for TaxoDros. We do not have abstracts.
M, Polak, W T, Starmer
openaire   +3 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Accurate recombination estimation from pooled genotyping and sequencing: a case study on barley

open access: yesBMC Genomics, 2022
Sexual reproduction involves meiotic recombination and the creation of crossing over between homologous chromosomes, which leads to new allele combinations. We present a new approach that uses the allele frequency differences and the physical distance of
Michael Schneider   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Bias in estimates of variance components in populations undergoing genomic selection: a simulation study

open access: yesBMC Genomics, 2019
Background After the extensive implementation of genomic selection (GS), the choice of the statistical model and data used to estimate variance components (VCs) remains unclear.
Hongding Gao   +5 more
doaj   +1 more source

Understanding the potential bias of variance components estimators when using genomic models

open access: yesGenetics Selection Evolution, 2018
Background Genomic models that link phenotypes to dense genotype information are increasingly being used for infering variance parameters in genetics studies.
Beatriz C. D. Cuyabano   +2 more
doaj   +1 more source

Impact of kinship matrices on genetic gain and inbreeding with optimum contribution selection in a genomic dairy cattle breeding program

open access: yesGenetics Selection Evolution, 2023
Background Genomic selection has increased genetic gain in dairy cattle, but in some cases it has resulted in higher inbreeding rates. Therefore, there is need for research on efficient management of inbreeding in genomically-selected dairy cattle ...
Egill Gautason   +3 more
doaj   +1 more source

How much can the orientation of G's eigenvectors tell us about genetic constraints? [PDF]

open access: yes, 2012
A key goal in evolutionary quantitative genetics is to understand how evolutionary trajectories are constrained by pleiotropic coupling among multiple traits.
Daniel Berner, Berner, Daniel
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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