Results 71 to 80 of about 851,465 (291)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
From genetical genomics to systems genetics: potential applications in quantitative genomics and animal breeding [PDF]
, 2018 This article reviews methods of integration of transcriptomics (and equally proteomics and metabolomics), genetics, and genomics in the form of systems genetics into existing genome analyses and their potential use in animal breeding and quantitative ...
Janss, Luc +2 more
core
Accurate recombination estimation from pooled genotyping and sequencing: a case study on barley
BMC Genomics, 2022 Sexual reproduction involves meiotic recombination and the creation of crossing over between homologous chromosomes, which leads to new allele combinations. We present a new approach that uses the allele frequency differences and the physical distance of
Michael Schneider +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
BMC Genomics, 2019 Background After the extensive implementation of genomic selection (GS), the choice of the statistical model and data used to estimate variance components (VCs) remains unclear.
Hongding Gao +5 more
doaj +1 more source
Understanding the potential bias of variance components estimators when using genomic models
Genetics Selection Evolution, 2018 Background Genomic models that link phenotypes to dense genotype information are increasingly being used for infering variance parameters in genetics studies.
Beatriz C. D. Cuyabano +2 more
doaj +1 more source
Genetics Selection Evolution, 2023 Background Genomic selection has increased genetic gain in dairy cattle, but in some cases it has resulted in higher inbreeding rates. Therefore, there is need for research on efficient management of inbreeding in genomically-selected dairy cattle ...
Egill Gautason +3 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Multiple-line inference of selection on quantitative traits
, 2015 Trait differences between species may be attributable to natural selection. However, quantifying the strength of evidence for selection acting on a particular trait is a difficult task.
Berg, Johannes +3 more
core +1 more source
Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. [PDF]
, 2019 The horse reference genome from the Thoroughbred mare Twilight has been available for a decade and, together with advances in genomics technologies, has led to unparalleled developments in equine genomics.
Bellone, R +3 more
core +2 more sources