Results 51 to 60 of about 391,632 (299)

Multiple Trait Covariance Association Test Identifies Gene Ontology Categories Associated with Chill Coma Recovery Time in Drosophila melanogaster

Scientific Reports, 2017
The genomic best linear unbiased prediction (GBLUP) model has proven to be useful for prediction of complex traits as well as estimation of population genetic parameters.
Izel Fourie Sørensen, Stefan M. Edwards, Palle Duun Rohde, Peter Sørensen   +3 more
doaj   +1 more source

Contribution of rare and low-frequency whole-genome sequence variants to complex traits variation in dairy cattle

Genetics Selection Evolution, 2017
Background Whole-genome sequencing and imputation methodologies have enabled the study of the effects of genomic variants with low to very low minor allele frequency (MAF) on variation in complex traits.
Qianqian Zhang, Mario P. L. Calus, Bernt Guldbrandtsen, Mogens Sandø Lund, Goutam Sahana   +4 more
doaj   +1 more source

Gene and QTL detection in a three-way barley cross under selection by a mixed model with kinship information using SNPs [PDF]

, 2011
Quantitative trait locus (QTL) detection is commonly performed by analysis of designed segregating populations derived from two inbred parental lines, where absence of selection, mutation and genetic drift is assumed.
Casas, Ana M., Ramsay, L., Fred A. van Eeuwijk, Mónica Elía, Bhat, Prasanna R., Malosetti, Marcos, Molina-Cano, José-Luis, Eeuwijk, F.A., van, Martin P. Boer, Luke Ramsay, van Eeuwijk, F.A., Molina-Cano, J.L., Elía, Mónica, Marian Moralejo, Ramsay, Luke, Boer, M., Eeuwijk, Fred A. van, Moralejo, Marian, Ramsay, Luke D., Ana M. Casas, Molina-Cano, José Luis, José-Luis Molina-Cano, Boer, Martin P., Moralejo, María Ángeles, Marcos Malosetti, Malosetti, M., Casas Cendoya, Ana María, Prasanna R. Bhat, Bhat, P., Casas, A., Elia, M., van Eeuwijk, Fred A.   +31 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Weighted single-step genomic best linear unbiased prediction integrating variants selected from sequencing data by association and bioinformatics analyses

Genetics Selection Evolution, 2020
Background Sequencing data enable the detection of causal loci or single nucleotide polymorphisms (SNPs) highly linked to causal loci to improve genomic prediction.
Aoxing Liu, Mogens Sandø Lund, Didier Boichard, Emre Karaman, Bernt Guldbrandtsen, Sebastien Fritz, Gert Pedersen Aamand, Ulrik Sander Nielsen, Goutam Sahana, Yachun Wang, Guosheng Su   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quantitative genetics in the age of omics [PDF]

Current Opinion in Plant Biology, 2008
The use of natural variation in the genetic dissection of quantitative traits has a long-standing tradition. Recent advances in high-throughput technologies for the quantification of biological molecules have shifted the focus in quantitative genetics from single traits to comprehensive large-scale analyses.
Keurentjes, J.J.B., Koornneef, M., Vreugdenhil, D.   +2 more
openaire   +4 more sources

From observational to dynamic genetics [PDF]

, 2014
Twin and family studies have shown that most traits are at least moderately heritable. But what are the implications of finding genetic influence for the design of intervention and prevention programs?
Oliver S. P. Davis, Davis, Oliver S. P., Claire M. A. Haworth, Oliver S.P. Davis, Haworth, Claire M. A., Claire M. A. Haworth, Davis, Oliver S P, Haworth, Claire M A   +7 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source