Results 61 to 70 of about 851,465 (291)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Quantitative Genetic Effects of Bottlenecks: Experimental Evidence from a Wild Plant Species, Nigella degenii [PDF]

, 2010
Understanding the genetic consequences of changes in population size is fundamental in a variety of contexts, such as adaptation and conservation biology.
Andersson, Anna Palmé, Arnold, Avery, Barton, Bittkau, Briggs, Bryant, Carson, Cheverud, Cohan, Comes, Ellmer, Falconer, Fernández, Flury, Friar, Goodnight, Hewitt, Houle, Jones, Jorgensen, Lande, Leberg, Lee, Lynch, Lynch, López-Fanjul, López-Fanjul, Maarten Ellmer, Nei, Newman, Phillips, Phillips, Phillips, Phillips, Robertson, Saccheri, Saccheri, Stefan Andersson, Strid, Strid, Swindell, Tove H. Jorgensen, van Heerwaarden, Wade, Wang, Whitlock, Whitlock, Whitlock, Widén, Willi, Willis, Wright, Wright, Zeng   +55 more
core   +1 more source

Balanced selection on purebred and crossbred performance increases gain in crossbreds

Genetics Selection Evolution, 2018
Background Genomic selection can be applied to select purebreds for crossbred performance (CP). The average performance of crossbreds can be considered as the summation of two components, i.e.
Hadi Esfandyari, Peer Berg, Anders Christian Sørensen   +2 more
doaj   +1 more source

Genome-wide association study on Fourier transform infrared milk spectra for two Danish dairy cattle breeds

BMC Genetics, 2020
Background Infrared spectral analysis of milk is cheap, fast, and accurate. Infrared light interacts with chemical bonds present inside the milk, which means that Fourier transform infrared milk spectra are a reflection of the chemical composition of ...
R. M. Zaalberg, L. Janss, A. J. Buitenhuis   +2 more
doaj   +1 more source

Metabolomic-genomic prediction can improve prediction accuracy of breeding values for malting quality traits in barley

Genetics Selection Evolution, 2023
Background Metabolomics measures an intermediate stage between genotype and phenotype, and may therefore be useful for breeding. Our objectives were to investigate genetic parameters and accuracies of predicted breeding values for malting quality (MQ ...
Xiangyu Guo, Pernille Sarup, Ahmed Jahoor, Just Jensen, Ole F. Christensen   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genome-wide identification and expression analysis of the SET domain-containing gene family in potato (Solanum tuberosum L.)

BMC Genomics
Genes containing the SET domain can catalyse histone lysine methylation, which in turn has the potential to cause changes to chromatin structure and regulation of the transcription of genes involved in diverse physiological and developmental processes ...
Vithusan Suppiyar, Venkata Suresh Bonthala, Asis Shrestha, Stephanie Krey, Benjamin Stich   +4 more
doaj   +1 more source

Statistical model and testing designs to increase response to selection with constrained inbreeding in genomic breeding programs for pigs affected by social genetic effects

Genetics Selection Evolution, 2021
Background Social genetic effects (SGE) are the effects of the genotype of one animal on the phenotypes of other animals within a social group. Because SGE contribute to variation in economically important traits for pigs, the inclusion of SGE in ...
Thinh Tuan Chu, Mark Henryon, Just Jensen, Birgitte Ask, Ole Fredslund Christensen   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Muller's ratchet and mutational meltdowns [PDF]

, 1993
We extend our earlier work on the role of deleterious mutations in the extinction of obligately asexual populations. First, we develop analytical models for mutation accumulation that obviate the need for time-consuming computer simulations in certain ...
Bürger, Reinhard, Gabriel, Wilfried, Lynch, Michael   +2 more
core   +1 more source