Results 61 to 70 of about 372,486 (255)

Theory and Practice in Quantitative Genetics [PDF]

Twin Research, 2003
With the rapid advances in molecular biology, the near completion of the human genome, the development of appropriate statistical genetic methods and the availability of the necessary computing power, the identification of quantitative trait loci has now become a realistic prospect for quantitative geneticists.
Posthuma, Daniëlle, Beem, A Leo, de Geus, Eco J C, van Baal, G Caroline M, Hjelmborg, Jacob v. B., Iachine, Ivan, Boomsma, Dorret I   +6 more
openaire   +2 more sources

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu, Masaharu Akiyama, Toshikazu Itabashi, Jun Hayakawa, Takahiro Kikuchi, Ryohei Fukunaga, Katsuyoshi Koh, Takahiro Ueda   +7 more
wiley   +1 more source

Bias in estimates of variance components in populations undergoing genomic selection: a simulation study

BMC Genomics, 2019
Background After the extensive implementation of genomic selection (GS), the choice of the statistical model and data used to estimate variance components (VCs) remains unclear.
Hongding Gao, Per Madsen, Gert Pedersen Aamand, Jørn Rind Thomasen, Anders Christian Sørensen, Just Jensen   +5 more
doaj   +1 more source

Understanding the potential bias of variance components estimators when using genomic models

Genetics Selection Evolution, 2018
Background Genomic models that link phenotypes to dense genotype information are increasingly being used for infering variance parameters in genetics studies.
Beatriz C. D. Cuyabano, A. Christian Sørensen, Peter Sørensen   +2 more
doaj   +1 more source

Impact of kinship matrices on genetic gain and inbreeding with optimum contribution selection in a genomic dairy cattle breeding program

Genetics Selection Evolution, 2023
Background Genomic selection has increased genetic gain in dairy cattle, but in some cases it has resulted in higher inbreeding rates. Therefore, there is need for research on efficient management of inbreeding in genomically-selected dairy cattle ...
Egill Gautason, Goutam Sahana, Bernt Guldbrandtsen, Peer Berg   +3 more
doaj   +1 more source

On the Quantitative Genetics of Mixture Characters [PDF]

Genetics, 2006
Abstract Finite mixture models are helpful for uncovering heterogeneity due to hidden structure. Quantitative genetics issues of continuous characters having a finite mixture of Gaussian components as statistical distribution are explored in this article.
Daniel, Gianola, Bjorg, Heringstad, Jorgen, Odegaard   +2 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improving genomic predictions by correction of genotypes from genotyping by sequencing in livestock populations

Journal of Animal Science and Biotechnology, 2019
Background Genotyping by sequencing (GBS) is a robust method to genotype markers. Many factors can influence the genotyping quality. One is that heterozygous genotypes could be wrongly genotyped as homozygotes, dependent on the genotyping depths. In this
Xiao Wang, Mogens Sandø Lund, Peipei Ma, Luc Janss, Haja N. Kadarmideen, Guosheng Su   +5 more
doaj   +1 more source