Results 121 to 130 of about 6,348,682 (283)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Hybrid PPO-GNN Framework for Adaptive Vehicle Routing Under Uncertainty: Application to Fuel Delivery Logistics

IEEE Access
Optimizing fuel delivery operations presents significant challenges due to stochastic demand, dynamic travel conditions, and complex operational constraints.
Majdi Argoubi, Khaled Mili
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Multi-objective optimization framework for sustainable olive oil supply chains: integrating environmental compliance with economic performance

Frontiers in Sustainability
IntroductionMediterranean olive oil production faces a critical sustainability challenge: managing olive mill wastewater (OMW), a highly polluting byproduct (0.8–1.2 m3/ton) threatening environmental compliance and supply chain viability.MethodsThis ...
Majdi Argoubi, Khaled Mili
doaj   +1 more source

Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers. [PDF]

Clin Proteomics, 2023
Kang N, Oh HJ, Hong JH, Moon HE, Kim Y, Lee HJ, Min H, Park H, Lee SH, Paek SH, Jin J.   +10 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage. [PDF]

Medicina (Kaunas), 2023
Simion L, Ionescu S, Chitoran E, Rotaru V, Cirimbei C, Madge OL, Nicolescu AC, Tanase B, Dicu-Andreescu IG, Dinu DM, Luca DC, Stanculeanu DL, Gheorghe AS, Zob D, Marincas M.   +14 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Bilevel DEA Model for Efficiency Evaluation and Target Setting with Stochastic Conditions

Mathematics
The effective allocation of limited resources and the establishment of targeted goals play a pivotal role in enhancing the overall efficiency of large enterprises and organizations.
Andreas C. Georgiou, Konstantinos Kaparis, Eleni-Maria Vretta, Kyriakos Bitsis, George Paltayian   +4 more
doaj   +1 more source

Utilising quantitative methods to study the intersectionality of multiple social disadvantages in women with common mental disorders: a systematic review. [PDF]

Int J Equity Health, 2023
Alghamdi NA, Dunn K, Cairns D, Melville C.   +3 more
europepmc   +1 more source