Results 161 to 170 of about 36,219,545 (383)

Flight test techniques for wake-vortex minimization studies [PDF]

open access: yes
Flight test techniques developed for use in a study of wake turbulence and used recently in flight studies of wake minimization methods are discussed. Flow visualization was developed as a technique for qualitatively assessing minimization methods and is
Barber, M. R., Jacobsen, R. A.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Predicting Mortality using Frailty Index and Latent Class Approaches: AUC-Based Evaluation in Simulated Data

open access: yesEpidemiology, Biostatistics and Public Health
BACKGROUND The global population is aging rapidly, creating significant challenges for healthcare systems [1]. Traditional disease-centered models often fail to meet the complex needs of older adults, who frequently have multiple chronic conditions ...
Donato Martella , Antonella Zambon
doaj   +1 more source

Integration of qualitative and quantitative methods for land-use-change modeling in a deforestation frontier. [PDF]

open access: yesConserv Biol, 2022
Siegel K   +5 more
europepmc   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

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