Results 71 to 80 of about 1,313,775 (264)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Quantitative models of auditory cortical processing. [PDF]
Hear Res, 2023 Sadagopan S, Kar M, Parida S.
europepmc +1 more source
Quantitative Modelling Biology Undergraduate Assessment
Letters in Biomathematics, 2019 The Quantitative Modelling Biology Undergraduate Assessment (QM BUGS Version II) assesses undergraduate biology students’ quantitative modelling abilities and confidence. The assessment is intended to be given in undergraduate biology courses where instructors are engaging students in quantitative modelling within biological contexts.
Mayes, Robert L. +3 more
openaire +4 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Quantitative recognition method for borehole trajectory models
Petroleum Exploration and Development, 2018 In order to accurately calculate drilled trajectories, the method of quantitatively recognizing borehole trajectory models was provided, and a case analysis was conducted.
Xiushan LIU
doaj +1 more source
Impact Energy Dissipation and Quantitative Models of Injection Molded Short Fiber-Reinforced Thermoplastics. [PDF]
Polymers (Basel), 2023 Jiang Q, Takayama T, Nishioka A.
europepmc +1 more source
Quantitative character dynamics: Gametic model [PDF]
Theoretical Population Biology, 1982 Abstract A gametic model of quantitative character dynamics is introduced that fills the gap between the two existing models: genic and zygotic/phenotypic. In this model, a gamete is treated as the elementary unit of evolution, all biological processes at the levels below gametic remain unspecified, and a gamete is characterized by its effect on the ...
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source