Results 111 to 120 of about 387,608 (286)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Imaging the cellular response to transient shear stress using time-resolved digital holography

, 2014
Shear stress has been recognized as one of the biophysical methods by which to permeabilize plasma membranes of cells. In particular, high pressure transient hydrodynamic flows created by laser-induced cavitation have been shown to lead to the uptake of ...
Arita, Yoshihiko, Antkowiak, Maciej, Dholakia, Kishan, Yoshihiko Arita, Maciej Antkowiak, Frank Gunn-Moore, Gunn-Moore, Frank, Kishan Dholakia   +7 more
core   +1 more source

Quantitative shearography: error reduction by using more than three measurement channels [PDF]

, 2011
Shearography is a noncontact optical technique used to measure surface displacement derivatives. Full surface strain characterization can be achieved using shearography configurations employing at least three measurement channels.
Charrett, Thomas O. H., Daniel Francis, Ralph P. Tatam, Tatam, Ralph P., Tom O. H. Charrett, Francis, Daniel   +5 more
core   +1 more source

Label-free functional analysis of root-associated microbes with dynamic quantitative oblique back-illumination microscopy

Scientific Reports
The increasing global demand for food, coupled with concerns about the environmental impact of synthetic fertilizers, underscores the urgency of developing sustainable agricultural practices.
Caroline E. Serafini, Madison Green, Abigail Diering, Marcus T. Cicerone, Lily S. Cheung, Joel E. Kostka, Francisco E. Robles   +6 more
doaj   +1 more source

Quantitative phase measurement in coherent diffraction imaging

Optics Express, 2008
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Clark, Jesse., Williams, G. J., Nugent, Keith A., Whitehead, L., de Jonge, M. D., Hanssen, Eric., Altissimo, M., Peele, Andrew Gareth., Quiney, H. M.   +8 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Computational field-resolved coherent chemical imaging

Nature Communications
Coherent Anti-Stokes Raman Scattering (CARS) has found critical applications across various fields, including high-speed chemical imaging, material science, and biomedical diagnostics.
Shupeng Zhao, Lea Chibani, Edward Chandler, Fangyu Liu, Jianqi Hu, Lorenzo Valzania, Ulugbek S. Kamilov, Hilton B. de Aguiar   +7 more
doaj   +1 more source

Study on Quantitative Phase Imaging by Dual-Wavelength Digital Holography Microscopy

International Journal of Optics, 2018
A dual-wavelength digital holographic microscopy with premagnification is proposed to obtain the object surface measurements over the large gradient. The quantitative phase images of specimens are captured in high precision by the processing of filtering
Lin Hu, Yunxiu Shui, Yaohui Dai, Haiyu Wu, Gang Zhu, Yan Yang   +5 more
doaj   +1 more source

Accurate quantitative phase imaging using generalized phase contrast

Optics Express, 2008
The generalized phase contrast (GPC) method is explored for improving the accuracy in quantitative reconstruction of two-dimensional phase distribution from images of semi-transparent objects viewed with a common-path interferometer (CPI). We propose a novel optical scheme for highly accurate determination of the object-dependent complex synthetic ...
Peter John, Rodrigo, Darwin, Palima, Jesper, Glückstad   +2 more
openaire   +2 more sources