Results 61 to 70 of about 857,162 (283)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Computational structured illumination for high-content fluorescent and phase microscopy [PDF]

, 2019
High-content biological microscopy targets high-resolution imaging across large fields-of-view (FOVs). Recent works have demonstrated that computational imaging can provide efficient solutions for high-content microscopy.
Chowdhury, Shwetadwip, Waller, Laura, Yeh, Li-Hao   +2 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Quantitative phase imaging with a multimode fiber

APL Photonics
Label-free quantitative phase imaging is vital for optical microscopy and metrology applications. A multimode fiber stands out as a desirable platform for imaging.
Aleksandra Ivanina, Maxim Marshall, Ksenia Abrashitova, Tristan van Leeuwen, Lyubov V. Amitonova   +4 more
doaj   +1 more source

The new neutron grating interferometer at the ANTARES beamline - Design, Principle, and Applications -

, 2016
Neutron grating interferometry is an advanced method in neutron imaging that allows the simultaneous recording of the transmission, the differential phase and the dark-field image.
Benedikt Betz, Michael Horisberger, Michael Schulz, Peter Böni, Sebastian Mühlbauer, Tommy Reimann   +5 more
core   +1 more source

Combined use of x-ray fluorescence microscopy, phase contrast imaging for high resolution quantitative iron mapping in inflamed cells [PDF]

, 2017
X-ray fluorescence microscopy (XRFM) is a powerful technique to detect and localize elements in cells. To derive information useful for biology and medicine, it is essential not only to localize, but also to map quantitatively the element concentration ...
Berlutti, Francesca, Bohic, S, C. Gramaccioni1, 4, Cloetens, P, Cutone, Antimo, Farruggia, G, Fratini, Michela, Iotti, S, Lagomarsino, S., Malucelli, E, Massimi, Lorenzo, Notargiacomo, Andrea, Pacureanu, A, Procopio, A, Rosa, Luigi, Valenti, Piera, Yang, Y   +16 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Optical diffraction tomography techniques for the study of cell pathophysiology

Journal of Biomedical Photonics & Engineering, 2016
Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, providing valuable information to reveal the mechanisms behind pathophysiology of cells and tissues.
Kyoohyun Kim, Jonghee Yoon, Seungwoo Shin, SangYun Lee, Su-A Yang, YongKeun Park   +5 more
doaj   +1 more source

Characterization of color cross-talk of CCD detectors and its influence in multispectral quantitative phase imaging [PDF]

, 2018
Multi-spectral quantitative phase imaging (QPI) is an emerging imaging modality for wavelength dependent studies of several biological and industrial specimens. Simultaneous multi-spectral QPI is generally performed with color CCD cameras. However, color
Ahluwalia, Balpreet Singh, Ahmad, Azeem, Butola, Ankit, Dubey, Vishesh, Kumar, Anand, Mehta, Dalip Singh   +5 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source