Results 61 to 70 of about 387,608 (286)

Optical diffraction tomography techniques for the study of cell pathophysiology

Journal of Biomedical Photonics & Engineering, 2016
Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, providing valuable information to reveal the mechanisms behind pathophysiology of cells and tissues.
Kyoohyun Kim, Jonghee Yoon, Seungwoo Shin, SangYun Lee, Su-A Yang, YongKeun Park   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Nonredundant Raman imaging using optical eigenmodes

, 2014
We thank funding from the UK Engineering and Physical Sciences Research Council namely grant EP/J01771X/1 and EU FP7 grant FAMOS.Various forms of imaging schemes have emerged over the last decade that are based on correlating variations in incident ...
Herrington, C. Simon, Herrington, C Simon, Kosmeier, Sebastian, Zolotovskaya, Svetlana A.; id_orcid, De Luca, Anna Chiara, Riches, Andrew C, Riches, Andrew, Zolotovskaya, Svetlana A., De Luca, Anna Ciara, Zolotovskaya, Svetlana, Dholakia, Kishan, Mazilu, Michael   +11 more
core   +1 more source

Transmission Structured Illumination Microscopy for Quantitative Phase and Scattering Imaging

Frontiers in Physics, 2021
In this paper, we demonstrate a digital micromirror device (DMD) based optical microscopic apparatus for quantitative differential phase contrast (qDIC) imaging, coherent structured illumination microscopy (SIM), and dual-modality (scattering/fluorescent)
Kai Wen, Ying Ma, Min Liu, Jianlang Li, Zeev Zalevsky, Juanjuan Zheng   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spatiotemporal characterization of a fibrin clot using quantitative phase imaging. [PDF]

PLoS ONE, 2014
Studying the dynamics of fibrin clot formation and its morphology is an important problem in biology and has significant impact for several scientific and clinical applications.
Rajshekhar Gannavarpu, Basanta Bhaduri, Krishnarao Tangella, Gabriel Popescu   +3 more
doaj   +1 more source

Deep Phase Shifter for Quantitative Phase Imaging

, 2020
A single intensity-only holographic interferogram can records the full amplitude and phase information of optical field. However, current digital holography technologies cannot recover the lossless phase information from a single interferogram. In this paper, we provide an entirely new approach for the full-field quantitative phase imaging technology ...
Zhang, Qinnan, Lu, Shengyu, Li, Jiaosheng, Li, Wenjie, Li, Dong, Lu, Xiaoxu, Zhong, Liyun, Tian, Jindong   +7 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Illumination coherence engineering and quantitative phase imaging [PDF]

Optics Letters, 2014
Partially coherent illumination provides significant advantages such as speckle-free imaging and enhanced optical sectioning in optical microscopy. The knowledge of the spatial and temporal coherence is crucial to obtain accurate quantitative phase imaging (QPI) of specimens such as live cells, micrometer-sized particles, etc.
Rodrigo Martín-Romo, José Augusto, Alieva Krasheninnikova, Tatiana   +1 more
openaire   +3 more sources