Results 51 to 60 of about 643,998 (303)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Applicable risk assessment methods in occupational and environmental exposure to nanoparticles - a narrative review [PDF]

Journal of Advances in Environmental Health Research, 2018
Nanoparticles (NPs) are a heterogeneous group of materials that have various applications, and their risk assessment is an essential condition. This study aimed to review the applicable risk assessment methods in occupational and environmental exposures ...
Ebrahim Darvishi, Reza Shahidi, Mohsen Mahdinia, Mohammad Javad Assari   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quantitative Assessment of Typhoon Disaster Risk at County Level

Journal of Marine Science and Engineering
Using the historical disaster records of 28 typhoons in Cangnan County since 2000, combining typhoon paths and hazard-bearing bodies data and based on the theoretical framework of climate change risk, the social and economic risks of typhoon disasters in
Guizhen Guo, Jie Yin, Lulu Liu, Shaohong Wu   +3 more
doaj   +1 more source

Quantitative Risk Assessment to Site Cng Refuelling Stations

Chemical Engineering Transactions, 2010
preview not available - see full-text PDF article.
N. Badri, F. Nouraei, D. Rashtchian
doaj   +1 more source

ENDÜSTRİYEL TESİSLERDE RİSK ANALİZİNE YÖNELİK KULLANILAN VERİ KAYNAKLARI VE BİR UYGULAMA

Eskişehir Osmangazi Üniversitesi Mühendislik ve Mimarlık Fakültesi Dergisi, 2020
Today's rapidly changing living conditions and increasing consumer needs lead to continuous differentiation of working conditions. This situation builds extra stress on workers which leads to possible new risks and dangers where it ...
Neslihan BABAARSLAN, Yavuz CABBAR
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Quantitative Risk Assessment on a Hydrogen Refuelling Station

Chemical Engineering Transactions, 2018
The Directive 2014/94/UE (DAFI, Alternative Fuel Initiative Directive) on the deployment of alternative fuels (i.e. hydrogen) infrastructures has been recently transposed into national law in Italy.
Paola Russo, Alessandra De Marco, Michele Mazzaro, Luigi Capobianco   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

How Useful Is Quantitative Risk Assessment? [PDF]

Risk Analysis, 2004
This article discusses the use of quantitative risk assessment (QRA) in decision making regarding the safety of complex technological systems. The insights gained by QRA are compared with those from traditional safety methods and it is argued that the two approaches complement each other.
openaire   +2 more sources