Results 51 to 60 of about 402,784 (308)

Thin-layer chromatography in quantitative structure-activity relationship studies

, 2018
The methods of correlating molecular structure of substances expressed as descriptors, to their biological activity are commonly denoted as Quantitative Structure-Activity Relationships (QSARs). This concept, typically applied in drug discovery processes,
Andrić, Filip, Šegan, Sandra, Tešić, Živoslav, Trifković, Jelena, Sandra Šegan, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., Filip Andrić, Šegan, Sandra B., Dušanka Milojković-Opsenica, Jelena Trifković, Živoslav Tešić   +11 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Quantitative structure-activity relationship of some 1-benzylbenzimidazole derivatives as antifungal agents [PDF]

Acta Periodica Technologica, 2007
In the present study, the antifungal activity of some 1-benzylbenzimidazole derivatives against yeast Saccharomyces cerevisiae was investigated. The tested benzimidazoles displayed in vitro antifungal activity and minimum inhibitory concentration (MIC ...
Podunavac-Kuzmanović Sanja O., Barna Dijana J., Cvetković Dragoljub D.   +2 more
doaj   +1 more source

Introductory Chapter: Some Quantitative Structure Activity Relationship Descriptor

, 2017
https://doi.org/10.5772/intechopen.69642https://www.intechopen.com/citation-pdf-url/56221http://www.intechopen.com/articles/show/title/introductory-chapter-some-quantitative-structure-activity-relationship-descriptorhttps://dx.doi.org/10.5772/intechopen ...
Kandemirli, Fatma, Fatma Kandemirli
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

3D-QSAR study and pharmacophore development of novel antidepressants affecting serotonine transporters and histamine H3 receptors [PDF]

, 2015
Depresija je najčešći mentalni poremećaj koji pogađa oko 350 miliona ljudi širom sveta. Selektivni inhibitori preuzimanja serotonina (SSRIs- Selective Serotonine Reuptake Inhibitors) su lekovi izbora u lečenju depresije.
Nikolić, Katarina, Agbaba, Danica, Đoković, Nemanja   +2 more
core  

Revealing quantitative structure-activity relationships of transport properties in acene and acene derivative organic materials

, 2010
The intermolecular electronic coupling (transfer integral) and the intramolecular vibronic coupling (reorganization energy) are key parameters determining the transport properties of organic electronic materials.
Wen, Shu-Hao, 韩克利, Han, Ke-Li, 邓伟侨, Deng, Wei-Qiao   +4 more
core   +1 more source

A practical overview of quantitative structure-activity relationship [PDF]

, 2009
Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library.
Isarankura-Na-Ayudhya, Chartchalerm, Nantasenamat, Chanin, Naenna, Thanakorn, Prachayasittikul, Virapong   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source