Results 91 to 100 of about 322,559 (240)

Additional file 5 of Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

, 2020
Liang‐Chin Huang, Wayland Yeung, Ye Wang, Huimin Cheng, Aarya Venkat, Sheng Li, Ping Ma, Khaled Rasheed, Natarajan Kannan   +8 more
openalex   +1 more source

Feature Extraction Methods in Quantitative Structure–Activity Relationship Modeling: A Comparative Study [PDF]

, 2020
Shrooq Alsenan, Isra Al-Turaiki, Alaaeldin M. Hafez   +2 more
openalex   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Quantitative structure-activity relationships for the acute toxicity of chlorobenzenes to Daphnia magna [PDF]

, 1985
Alice M. Bobra, Wan Ying Shiu, Donald Mackay   +2 more
openalex   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Quantitative Structure-Activity Relationship Study of Fatty Acid Derivatives as Lubricant Additive

Jurnal Rekayasa Kimia & Lingkungan
Fatty acid compounds and their derivatives have been known in tribology as a source of bio-lubricant raw materials. New compounds were developed computationally to sort out the physical properties of the desired lubricant additive before synthesis in the
Rahmawita Sugesti, Komar Sutriah, Mohammad Khotib   +2 more
doaj   +1 more source

Soft‐Layered Composites with Wrinkling‐Activated Multi‐Linear Elastic Behavior, Stress Mitigation, and Enhanced Strain Energy Storage

Advanced Engineering Materials, EarlyView.
In this study, exciting new bi‐/multi‐linear elastic behavior of soft elastic composites that accompany the activation of wrinkling in the embedded interfacial layers is analyzed. The new features and performance of these composite materials, including dramatic enhancements in energy storage, can be tailored by the concentration of interfacial layers ...
Narges Kaynia, Nicholas Xuanlai Fang, Mary C. Boyce   +2 more
wiley   +1 more source

Quantitative Structure - Activity Relationships Study of Carbonic Anhydrase Inhibitors Using Logistic Regression Model [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2013
Binary Logistic Regression (BLR) has been developed as non-linear models to establish quantitative structure- activity relationships (QSAR) between structural descriptors and biochemical activity of carbonic anhydrase inhibitors.
Hassan Sahebjamee, Parichehre Yaghmaei, Parviz Abdolmaleki, Ali Reza Foroumadi   +3 more
doaj  

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

Advanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani, Aditi Singh, Behnam Ashrafi   +2 more
wiley   +1 more source