Results 101 to 110 of about 400,566 (302)

Quantitative structure-activity relationship study of some 7-substituted theophyllines

, 1998
Some novel 7-substituted theophylline derivatives have been investigated for quantitative structure-activity relationship (QSAR). For this purpose, their bronchodilatory activities (in vitro), which were examined by the inhibition of acetylcholine ...
Akgun, H, Balkan, A, Türker, Burhan Lemi   +2 more
core   +1 more source

Chemometric Methodologies in a Quantitative Structure-Activity Relationship Study: the Antibacterial Activity of 6-Aminoquinolones

, 1997
The paper illustrates the chemometric strategies appropriate for extracting information from a large amount of biological data regarding the antibiotic activity of 6-aminoquinolones.
FRAVOLINI, Arnaldo, BONELLI, Daniela, TABARRINI, Oriana, FILIPPONI, Enrica, M. Clementi, CECCHETTI, Violetta, CRUCIANI, Gabriele, CLEMENTI, Sergio   +7 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Deep learning for chemoinformatics

大数据, 2017
Deep learning have been successfully used in computer vision，speech recognition and natural language processing，leading to the rapid development of artificial intelligence.The key technology of deep learning was also applied to chemoinformatics，speeding ...
Youjun XU, Jianfeng PEI
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Modeling of the Acute Toxicity of Benzene Derivatives by Complementary QSAR Methods

, 2013
A data set containing acute toxicity values (96-h LC50) of 69 substituted benzenes for fathead minnow (Pimephales promelas) was investigated with two Quantitative Structure- Activity Relationship (QSAR) models, either using or not using molecular ...
Duce, Celia, Solaro, Roberto, Héberger, Károly, Bertinetto, Carlo   +3 more
core  

Quantitative Nanostructure−Activity Relationship Modeling

, 2010
Evaluation of biological effects, both desired and undesired, caused by Manufactured NanoParticles (MNPs) is of critical importance for nanotechnology.
Carlos Tassa, Dongqiuye Pu, Shaw, Stanley Y., Pu, Dongqiuye, Weissleder, Ralph, Tropsha, Alexander, Denis Fourches, Stanley Y. Shaw, Alexander Tropsha, Ralph Weissleder, Tassa, Carlos, Russell J. Mumper, Fourches, Denis, Mumper, Russell J.   +13 more
core   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Quantitative Nanostructure−Activity Relationship Modeling

, 2016
Evaluation of biological effects, both desired and undesired, caused by manufactured nanoparticles (MNPs) is of critical importance for nanotechnology.
Denis Fourches (395905), Stanley Y. Shaw (150648), Russell J. Mumper (516486), Carlos Tassa (2024263), Alexander Tropsha (1308912), Dongqiuye Pu (2257240), Ralph Weissleder (60)   +6 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source