Results 91 to 100 of about 19,356,818 (281)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Thin-layer chromatography in quantitative structure-activity relationship studies

, 2018
The methods of correlating molecular structure of substances expressed as descriptors, to their biological activity are commonly denoted as Quantitative Structure-Activity Relationships (QSARs). This concept, typically applied in drug discovery processes,
Andrić, Filip, Šegan, Sandra, Tešić, Živoslav, Trifković, Jelena, Sandra Šegan, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., Filip Andrić, Šegan, Sandra B., Dušanka Milojković-Opsenica, Jelena Trifković, Živoslav Tešić   +11 more
core   +1 more source

Quantitative structure-activity relationship study of xanthene derivatives

, 2018
Xanthenes are important class of biologically active compounds due to their broad spectrum of pharmacological activities such as bactericidial, anti-inflammatory, antiviral and antiproliferative activity.
Nikolić, Katarina, Završnik, Davorka, Špirtović- Halilović, Selma, Muratović, S, Veljović, Elma, Zukić, Selma, Osmanović, Amar, Oljačić, Slavica   +7 more
core   +5 more sources

Structure-Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis [PDF]

, 2017
Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan, Alfain Noerdin Alimny, Diah Amelia, Wiwin Retnowati, NIDN. 0009046803, Sri Puji Astuti Wahyuningsih, NIDN. 0021026604   +4 more
core   +1 more source

Deep learning for chemoinformatics

大数据, 2017
Deep learning have been successfully used in computer vision，speech recognition and natural language processing，leading to the rapid development of artificial intelligence.The key technology of deep learning was also applied to chemoinformatics，speeding ...
Youjun XU, Jianfeng PEI
doaj  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Synthesis, characterization, cytotoxic screening, and density functional theory studies of new derivatives of quinazolin-4(3H)-one Schiff bases

Research in Pharmaceutical Sciences, 2017
A series of novel derivatives of quinazolinone Schiff bases were synthesized from benzoic acid starting material and evaluated for potential cytotoxic activities against the human breast adenocarcinoma (MCF-7) and the human colon adenocarcinoma (HT-29 ...
Rezvan Rezaee Nasab, Farshid Hassanzadeh, Ghadam Ali Khodarahmi, Mahmoud Mirzaei, Mahboubeh Rostami, Ali Jahanian-Najaf abadi   +5 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Introductory Chapter: Some Quantitative Structure Activity Relationship Descriptor

, 2017
https://doi.org/10.5772/intechopen.69642https://www.intechopen.com/citation-pdf-url/56221http://www.intechopen.com/articles/show/title/introductory-chapter-some-quantitative-structure-activity-relationship-descriptorhttps://dx.doi.org/10.5772/intechopen ...
Kandemirli, Fatma, Fatma Kandemirli
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source