Results 41 to 50 of about 402,830 (348)

The heuristic-direct approach to quantitative structure-activity relationship analysis

, 1993
The heuristic-direct approach to quantitative structure-activity relationship ...
COCCHI, Marina, FANELLI, Francesca, M.Cristina Menziani, Francesca Fanelli, Pier G. De Benedetti, DE BENEDETTI, Pier Giuseppe, MENZIANI, Maria Cristina, Marina Cocchi   +7 more
core   +1 more source

Assessing the Effects of Alloxydim Phototransformation Products by QSAR Models and a Phytotoxicity Study

Molecules, 2018
Once applied, an herbicide first makes contact with leaves and soil. It is known that photolysis can be one of the most important processes of dissipation of herbicides in the field.
Juan J. Villaverde, Inés Santín-Montanyá, Beatriz Sevilla-Morán, José L. Alonso-Prados, Pilar Sandín-España   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

LIPOPHILICITY AND ANTIFUNGAL ACTIVITY OF SOME 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2011
In the present paper, the antifungal activity of some 2-methyl and 2-amino-benzimidazole derivatives was evaluated against yeast Saccharomyces cere¬visiae. The tested compounds displayed in vitro antifungal activity and mini¬mum inhibitory concentration (
SANJA O. PODUNAVAC-KUZMANOVIĆ, DRAGOLJUB D. CVETKOVIĆ   +1 more
doaj  

Quantitative structure-activity relationship to elucidate human CYP2A6 inhibition by organosulfur compounds

ADMET and DMPK, 2019
CYP2A6 is a human enzyme responsible for the metabolic elimination of nicotine, and it is also involved in the activation of procarcinogenic nitrosamines, especially those present in tobacco smoke.
Daniela Andrea Ramirez, Eduardo Marchevsky, Juan Maria Luco, Alejandra Camargo   +3 more
doaj   +1 more source

Toward Novel Antioxidant Drugs: Quantitative Structure-Activity Relationship Study of Eugenol Derivatives

Walisongo Journal of Chemistry, 2021
The study of the Quantitative Structure-Activity Relationship (QSAR) of eugenol compound and its derivatives towards antioxidant activities was conducted using electronic and molecular descriptors.
Priyagung Dhemi Widiakongko, Karisma Triatmaja   +1 more
doaj   +1 more source

Docking and QSAR studies of an indirect estrogenic effect of hydroxylated PCBs

, 2002
A quantitative structure-activity relationship (QSAR) of hydroxylated polychlorinated biphenyls (OH-PCBs) potency to inhibit human estrogen sulfotransferase (hEST), was modeled using multivariate methods and calculated semi-empirical descriptors.
Andersson, Patrik,, Heimstad, Eldbjørg S   +1 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source