Results 41 to 50 of about 2,779 (160)

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Changes of deep gray matter magnetic susceptibility over 2years in multiple sclerosis and healthy control brain

NeuroImage: Clinical, 2018
In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique ...
Jesper Hagemeier, Robert Zivadinov, Michael G. Dwyer, Paul Polak, Niels Bergsland, Bianca Weinstock-Guttman, Joshua Zalis, Andreas Deistung, Jürgen R. Reichenbach, Ferdinand Schweser   +9 more
doaj   +1 more source

Low thalamostriate venous quantitative susceptibility measurements correlate with higher presenting NIH stroke scale score in emergent large vessel occlusion stroke

Journal of International Medical Research, 2020
Objective Hyperacute stroke affects various patient subgroups who may benefit from different management strategies. Magnetic resonance imaging (MRI) quantitative susceptibility mapping (QSM) is a recent MRI technique for measuring deoxyhemoglobin levels.
Paggie Kim, Kristofer Langheinrich, Brian Cristiano, Phillip Grigsby, Udo Oyoyo, Daniel Kido, J. Paul Jacobson   +6 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Quantitative susceptibility mapping to evaluate the early stage of Alzheimer's disease

NeuroImage: Clinical, 2017
The objective of this study was to evaluate susceptibility changes caused by iron accumulation in cognitive normal (CN) elderly, those with amnestic mild cognitive impairment (aMCI), and those with early state AD, and to compare the findings with gray ...
Hyug-Gi Kim, Soonchan Park, Hak Young Rhee, Kyung Mi Lee, Chang-Woo Ryu, Sun Jung Rhee, Soo Yeol Lee, Yi Wang, Geon-Ho Jahng   +8 more
doaj   +1 more source

AI‐Powered Gradient Echo Plural Contrast Imaging (AI‐GEPCI)—A Comprehensive Neurological Protocol From a Single MRI Scan

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MRI is essential for diagnosing and monitoring neurological diseases. Conventional protocols require multiple sequences to obtain complementary contrasts, increasing scan time, cost, and tolerability. Generating multiple contrasts from a single acquisition may streamline workflow while maintaining clinical utility.
Jeramy Lewis, Manu S. Goyal, Gregory F. Wu, Yuyang Hu, Alexander L. Sukstanskii, Satya V. V. N. Kothapalli, Anne H. Cross, Ulugbek Kamilov, Dmitriy A. Yablonskiy   +8 more
wiley   +1 more source

NoQSM-net: Combining Convolutional Neural Network With Numerical Optimization Algorithm for Quantitative Susceptibility Mapping Reconstruction

IEEE Access
In gradient echo MRI, quantitative susceptibility mapping (QSM) quantifies the magnetic susceptibility distributions of tissues, which has great potential in detecting brain diseases.
Qianqian Zhang, Yihao Guo, Wufan Chen
doaj   +1 more source

Instant tissue field and magnetic susceptibility mapping from MRI raw phase using Laplacian enhanced deep neural networks

NeuroImage, 2022
Quantitative susceptibility mapping (QSM) is an MRI post-processing technique that produces spatially resolved magnetic susceptibility maps from phase data.
Yang Gao, Zhuang Xiong, Amir Fazlollahi, Peter J Nestor, Viktor Vegh, Fatima Nasrallah, Craig Winter, G. Bruce Pike, Stuart Crozier, Feng Liu, Hongfu Sun   +10 more
doaj   +1 more source

Quantitative Assessment of Visible Nigrosome‐1 in Patients with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The nigrosome‐1 (N1) sign on susceptibility‐weighted imaging (SWI) typically disappears in Parkinson's disease (PD), though some patients can show uni−/bilaterally preserved N1. Objective Investigating whether visible nigrosomes in PD patients differ from those of healthy subjects (HC). Methods Forty‐eight PD and 35 HC underwent 3 T‐
Maria Eugenia Caligiuri, Ilaria Chimento, Marida De Maria, Emma Biondetti, Jolanda Buonocore, Valerio Riccardo Aquila, Maria Celeste Bonacci, Emanuele Tinelli, Umberto Sabatini, Aldo Quattrone, Andrea Quattrone   +10 more
wiley   +1 more source