Results 61 to 70 of about 2,739 (132)

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology
Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on ...
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
doaj   +1 more source

Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study

Journal of Imaging
This study aims to demonstrate the feasibility of ultrashort echo time (UTE)-based susceptibility source separation for musculoskeletal (MSK) imaging, enabling discrimination between diamagnetic and paramagnetic tissue components, with a particular focus
Sam Sedaghat, Jin Il Park, Eddie Fu, Annette von Drygalski, Yajun Ma, Eric Y. Chang, Jiang Du, Lorenzo Nardo, Hyungseok Jang   +8 more
doaj   +1 more source

AI‐Powered Gradient Echo Plural Contrast Imaging (AI‐GEPCI)—A Comprehensive Neurological Protocol From a Single MRI Scan

Journal of Magnetic Resonance Imaging, Volume 64, Issue 2, Page 346-358, August 2026.
ABSTRACT Background MRI is essential for diagnosing and monitoring neurological diseases. Conventional protocols require multiple sequences to obtain complementary contrasts, increasing scan time, cost, and tolerability. Generating multiple contrasts from a single acquisition may streamline workflow while maintaining clinical utility.
Jeramy Lewis, Manu S. Goyal, Gregory F. Wu, Yuyang Hu, Alexander L. Sukstanskii, Satya V. V. N. Kothapalli, Anne H. Cross, Ulugbek Kamilov, Dmitriy A. Yablonskiy   +8 more
wiley   +1 more source

Quantitative Assessment of Visible Nigrosome‐1 in Patients with Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1951-1957, August 2026.
Abstract Background The nigrosome‐1 (N1) sign on susceptibility‐weighted imaging (SWI) typically disappears in Parkinson's disease (PD), though some patients can show uni−/bilaterally preserved N1. Objective Investigating whether visible nigrosomes in PD patients differ from those of healthy subjects (HC). Methods Forty‐eight PD and 35 HC underwent 3 T‐
Maria Eugenia Caligiuri, Ilaria Chimento, Marida De Maria, Emma Biondetti, Jolanda Buonocore, Valerio Riccardo Aquila, Maria Celeste Bonacci, Emanuele Tinelli, Umberto Sabatini, Aldo Quattrone, Andrea Quattrone   +10 more
wiley   +1 more source

MRI-Based Quantification of Magnetic Susceptibility in Gel Phantoms: Assessment of Measurement and Calculation Accuracy

Radiology Research and Practice, 2018
The local magnetic field inside and around an object in a magnetic resonance imaging unit depends on the magnetic susceptibility of the object being magnetized, in combination with its geometry/orientation.
Emma Olsson, Ronnie Wirestam, Emelie Lind   +2 more
doaj   +1 more source

Mesoscale Whole‐Brain T2*‐Weighted and Associated Quantitative MRI in Humans at 10.5 T

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 817-825, August 2026.
ABSTRACT Purpose To demonstrate mesoscale whole‐brain T2*‐weighted (T2*w) MRI at 10.5 T, quantify R2* relaxation rate and magnetic susceptibility (χ), and evaluate T2*w contrast at such high field strength. Methods Multi‐echo GRE (ME‐GRE) data were collected in healthy adults at 0.5 mm isotropic resolution at 10.5 T.
Jiaen Liu, Peter van Gelderen, Jacco A. de Zwart, Jeff H. Duyn, Yujia Huang, Shuxian Qu, Andrea Grant, Edward J. Auerbach, Matt Waks, Russell L. Lagore, Lance Delabarre, Alireza Sadeghi‐Tarakameh, Yigitcan Eryaman, Gregor Adriany, Kamil Uğurbil, Xiaoping Wu   +15 more
wiley   +1 more source

Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM) of Highly Concentrated Magnetic Nanoparticles: A Comparison Study about Different Sampling Strategies

Molecules, 2019
The ability to accurately and non-invasively quantify highly concentrated magnetic nanoparticles (MNPs) is desirable for many emerging applications. Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) has demonstrated the capability to ...
Xing Lu, Hyungseok Jang, Yajun Ma, Saeed Jerban, Eric Y. Chang, Jiang Du   +5 more
doaj   +1 more source

Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
This work analyzed healthy brain lifespan trajectories of paramagnetic iron and diamagnetic myelin with three common susceptibility source separation methods (χ‐separation, χ‐sepnet and APART‐QSM). Deep gray and white matter regions of 339 subjects (5–90 years) were studied.
Tereza Beatriz Oliveira Assunção, Nashwan Naji, Peter Seres, Christian Beaulieu, Alan H. Wilman   +4 more
wiley   +1 more source

Quantitative susceptibility and T1ρ mapping of knee articular cartilage at 3T

Osteoarthritis and Cartilage Open
T1ρ and Quantitative Susceptibility Mapping (QSM) are evolving as substrates for quantifying the progressive nature of knee osteoarthritis. Objective: To evaluate the effects of spin lock time combinations on depth-dependent T1ρ estimation, in adjunct to
Allen A. Champagne, Taylor M. Zuleger, Daniel R. Smith, Alexis B. Slutsky-Ganesh, Shayla M. Warren, Mario E. Ramirez, Lexie M. Sengkhammee, Sagar Mandava, Hongjiang Wei, Davide D. Bardana, Joseph D. Lamplot, Gregory D. Myer, Jed A. Diekfuss   +12 more
doaj   +1 more source

Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

Frontiers in Aging Neuroscience
BackgroundIron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer’s disease (AD) and can be measured using quantitative susceptibility mapping (QSM).
Neha Singh-Reilly, Ryota Satoh, Jonathan Graff-Radford, Mary M. Machulda, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell   +6 more
doaj   +1 more source