Results 51 to 60 of about 4,917,448 (190)

Generalized Dystonia With Cervical Predominance in a Patient With a De Novo TCF20 Variant

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT TCF20 has been implicated in developmental delay and intellectual disability, with dystonia reported less frequently. We describe a woman in her early twenties with childhood‐onset learning difficulties, progressive dysarthria, tremor, and generalized dystonia with marked cervical predominance, associated with a de novo TCF20 frameshift ...
Melisa Kilic, Petr Dusek, Ibrahim Kamaci, Bahar Gulmez, Gul Yalcin Cakmakli, Ersin Tan, Sibel Ugur Iseri, Zuhal Yapici   +7 more
wiley   +1 more source

Quantitative Susceptibility Mapping in Parkinson's Disease.

PLoS ONE, 2016
BackgroundQuantitative susceptibility mapping (QSM) and R2* relaxation rate mapping have demonstrated increased iron deposition in the substantia nigra of patients with idiopathic Parkinson's disease (PD).
Christian Langkammer, Lukas Pirpamer, Stephan Seiler, Andreas Deistung, Ferdinand Schweser, Sebastian Franthal, Nina Homayoon, Petra Katschnig-Winter, Mariella Koegl-Wallner, Tamara Pendl, Eva Maria Stoegerer, Karoline Wenzel, Franz Fazekas, Stefan Ropele, Jürgen Rainer Reichenbach, Reinhold Schmidt, Petra Schwingenschuh   +16 more
doaj   +1 more source

Affine transformation edited and refined deep neural network for quantitative susceptibility mapping

NeuroImage, 2023
Deep neural networks have demonstrated great potential in solving dipole inversion for Quantitative Susceptibility Mapping (QSM). However, the performances of most existing deep learning methods drastically degrade with mismatched sequence parameters ...
Zhuang Xiong, Yang Gao, Feng Liu, Hongfu Sun   +3 more
doaj   +1 more source

Four‐Year Cognitive Outcomes in Multiple Sclerosis: Associations With Lesion Myelin Integrity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Cognitive impairment is prevalent in patients with multiple sclerosis (MS) but whether lesion myelin integrity influences future cognitive outcomes remains unclear. We investigated the relationship between baseline lesion myelin water fraction (MWF) and cognitive performance 4 years later.
Iliana Pliska‐Bloch, Hannah Schwartz, Kimberly H. Markowitz, Abhishek Jaywant, Christopher D. Hildenbrand, Jai Perumal, Ulrike W. Kaunzner, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Changes of deep gray matter magnetic susceptibility over 2years in multiple sclerosis and healthy control brain

NeuroImage: Clinical, 2018
In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique ...
Jesper Hagemeier, Robert Zivadinov, Michael G. Dwyer, Paul Polak, Niels Bergsland, Bianca Weinstock-Guttman, Joshua Zalis, Andreas Deistung, Jürgen R. Reichenbach, Ferdinand Schweser   +9 more
doaj   +1 more source

Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study. [PDF]

J Magn Reson Imaging
ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Wang K, Wang J, Diao Z, Tan X, Qiu S, An J.   +5 more
europepmc   +2 more sources

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

Annals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola, Maija Saraste, Edoardo Pedrini, Joel Tuomaala, Luzia Buchholz, Markus Matilainen, Johanna Lindenberg, Eeva‐Christine Brockmann, Maria Sofia Martire, Sofia Sandgren, David Leppert, Jens Kuhle, Tanja Kuhlmann, Martina Absinta, Laura Airas   +14 more
wiley   +1 more source

Low thalamostriate venous quantitative susceptibility measurements correlate with higher presenting NIH stroke scale score in emergent large vessel occlusion stroke

Journal of International Medical Research, 2020
Objective Hyperacute stroke affects various patient subgroups who may benefit from different management strategies. Magnetic resonance imaging (MRI) quantitative susceptibility mapping (QSM) is a recent MRI technique for measuring deoxyhemoglobin levels.
Paggie Kim, Kristofer Langheinrich, Brian Cristiano, Phillip Grigsby, Udo Oyoyo, Daniel Kido, J. Paul Jacobson   +6 more
doaj   +1 more source

Instant tissue field and magnetic susceptibility mapping from MRI raw phase using Laplacian enhanced deep neural networks

NeuroImage, 2022
Quantitative susceptibility mapping (QSM) is an MRI post-processing technique that produces spatially resolved magnetic susceptibility maps from phase data.
Yang Gao, Zhuang Xiong, Amir Fazlollahi, Peter J Nestor, Viktor Vegh, Fatima Nasrallah, Craig Winter, G. Bruce Pike, Stuart Crozier, Feng Liu, Hongfu Sun   +10 more
doaj   +1 more source