Results 81 to 90 of about 4,607 (203)

Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways

Addiction, EarlyView.
Abstract Background and aims Tobacco smoking is a major risk factor for cardiovascular and lung diseases. A better understanding of its neurobiological underpinnings will benefit the prevention of smoking‐related illnesses and mortality. Previous studies link smoking to increased iron concentration in the striatum, a central component of the brain's ...
Olga Trofimova, Ilaria Iuliani, Sven Bergmann   +2 more
wiley   +1 more source

Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI‐Based Meta‐Analysis

Annals of the New York Academy of Sciences, EarlyView.
Iron is crucial for brain functioning, but excessive levels can harm brain health. While previous studies support this, meta‐analytic evidence in Alzheimer's disease (AD) is limited. We performed a meta‐analysis of 23 MRI studies with 715 AD patients and 1130 healthy controls.
Marthe Mieling, Clara Wiskow, Nico Bunzeck   +2 more
wiley   +1 more source

Morphology-adaptive total variation for the reconstruction of quantitative susceptibility map from the magnetic resonance imaging phase. [PDF]

PLoS ONE, 2018
Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging technique that quantifies the magnetic susceptibility distribution within biological tissues.
Li Guo, Yingjie Mei, Jijing Guan, Xiangliang Tan, Yikai Xu, Wufan Chen, Qianjin Feng, Yanqiu Feng   +7 more
doaj   +1 more source

Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study [PDF]

, 2019
Deep gray matter involvement is a consistent feature in multiple sclerosis. The aim of this study was to evaluate the relationship between different deep gray matter alterations and the development of subcortical atrophy, as well as to investigate the ...
Borrelli, P, Brunetti, A, Cocozza, S, Criscuolo, C, Elefante, A, Lanzillo, R, Morra, V B, Palma, G, Paolella, C, Pontillo, G, Russo, C, Stasi, M D, Tedeschi, E, Vola, E A   +13 more
core   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Experimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source

Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: Interpreting positive susceptibility and the presence of iron [PDF]

Magnetic Resonance in Medicine, 2014
PurposeWithin multiple sclerosis (MS) lesions iron is present in chronically activated microglia. Thus, iron detection with MRI might provide a biomarker for chronic inflammation within lesions. Here, we examine contributions of iron and myelin to magnetic susceptibility of lesions on quantitative susceptibility mapping (QSM).MethodsFixed MS brain ...
Cynthia, Wisnieff, Sriram, Ramanan, John, Olesik, Susan, Gauthier, Yi, Wang, David, Pitt   +5 more
openaire   +2 more sources

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Harmonic field extension for QSM with reduced spatial coverage using physics-informed generative adversarial network

NeuroImage
Quantitative susceptibility mapping (QSM) is frequently employed in investigating brain iron related to brain development and diseases within deep gray matter (DGM). Nonetheless, the acquisition of whole-brain QSM data is time-intensive.
Siyun Jung, Soohyun Jeon, Sung-Min Gho, Ho-Joon Lee, Kyu-Jin Jung, Dong-Hyun Kim   +5 more
doaj   +1 more source

Diagnostic accuracy of semiautomatic lesion detection plus quantitative susceptibility mapping in the identification of new and enhancing multiple sclerosis lesions

NeuroImage: Clinical, 2018
Purpose: To evaluate the diagnostic accuracy of a novel non-contrast brain MRI method based on semiautomatic lesion detection using T2w FLAIR subtraction image, the statistical detection of change (SDC) algorithm (T2w + SDC), and quantitative ...
Shun Zhang, Thanh D. Nguyen, Yize Zhao, Susan A. Gauthier, Yi Wang, Ajay Gupta   +5 more
doaj   +1 more source

Phase-based regional oxygen metabolism (PROM) using MRI [PDF]

, 2011
Venous oxygen saturation (Yv) in cerebral veins and the cerebral metabolic rate of oxygen (CMRO2) are important indicators for brain function and disease.
Chen, Clark, Davis, de Rochefort, Donahue, Duyn, Fernandez-Seara, Fernandez-Seara, Gallagher, Gardener, Guyton, Haacke, Hattori, Ibaraki, Ishii, Ishii, Ito, Ito, Jain, Kety, Langham, Langham, Lathi, Lin, Liu, Lu, Luh, Magistretti, Marques, Miles, Mintun, Plyavin, Schenck, Sobesky, Spees, Thompson, Thulborn, Vaishnavi, van Zijl, Viswanathan, Wang, Weisskoff, Xu   +42 more
core   +1 more source