Results 141 to 150 of about 267,706 (322)

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Sensory conflict in motion sickness: An observer theory approach [PDF]

Motion sickness is the general term describing a group of common nausea syndromes originally attributed to motion-induced cerebral ischemia, stimulation of abdominal organ afferent, or overstimulation of the vestibular organs of the inner ear. Sea-, car-,
Oman, Charles M.
core   +1 more source

Assessing the synergy between cholinomimetics and memantine as augmentation therapy in cognitive impairment in schizophrenia. A virtual human patient trial using quantitative systems pharmacology [PDF]

, 2015
Hugo Geerts, Patrick J. Roberts, Äthan Spiros   +2 more
openalex   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Quantitative Systems Pharmacology Models for a New International Cardiac Safety Regulatory Paradigm: An Overview of the Comprehensive In Vitro Proarrhythmia Assay In Silico Modeling Approach [PDF]

, 2019
Zhihua Li, Christine Garnett, David G. Strauss   +2 more
openalex   +1 more source

Dose Regimen Optimization of PD-L1 Inhibitor and Nab-paclitaxel in Patients with NSCLC: a Quantitative Systems Pharmacology analysis [PDF]

, 2022
Chenyu Wang, Dihong Yang, Xiaomin Niu, Lu Han, Wen Wang, Roman Filimonov, Sajid Ali Shah, Xin-yang Weng, Zheng Jiao   +8 more
openalex   +1 more source

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Exploring Tafamidis Effects Through PBPK–QSP Modelling

Pharmaceutics
Background/Objectives: Tafamidis, a transthyretin kinetic stabilizer, increases circulating transthyretin levels in treated patients. While this effect is well documented, its underlying mechanism remains incompletely understood.
Seweryn Ulaszek, Bartek Lisowski, Barbara Wiśniowska, Sebastian Polak   +3 more
doaj   +1 more source

Quantitative systems pharmacology model for Alzheimer’s disease to predict the effect of aducanumab on brain amyloid

, 2022
Lin Lin, Fei Hua, Cristian Salinas, Carissa L. Young, Thierry Bussière, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov   +9 more
openalex   +1 more source

A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions [PDF]

, 2023
Rohit Rao, Cynthia J. Musante, Richard Allen   +2 more
openalex   +1 more source