Results 141 to 150 of about 95,693 (243)

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Leveraging quantitative systems pharmacology modeling for elranatamab regimen optimization in relapsed or refractory multiple myeloma. [PDF]

NPJ Syst Biol Appl
Poels KE, Elmeliegy M, Hibma J, Wang D, Musante CJ, Shtylla B.   +5 more
europepmc   +1 more source

Quantitative systems pharmacology model of erythropoiesis to simulate therapies targeting anemia due to chronic kidney disease. [PDF]

Front Pharmacol, 2023
Roy M, Saroha S, Sarma U, Sarathy H, Kumar R.   +4 more
europepmc   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

A quantitative systems pharmacology approach to support mRNA vaccine development and optimization

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gianluca Selvaggio, Lorena Leonardelli, Giuseppe Lofano, Stephanie Fresnay, Silvia Parolo, Duccio Medini, Emilio Siena, Luca Marchetti   +7 more
doaj   +1 more source

Integrating Pharmacokinetics and Quantitative Systems Pharmacology Approaches in Generative Drug Design. [PDF]

J Chem Inf Model
van den Maagdenberg HW, de Mol van Otterloo J, van Hasselt JGC, van der Graaf PH, van Westen GJP.   +4 more
europepmc   +1 more source

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Ji Y, Madrasi K, Knee DA, Gruenbaum L, Apgar JF, Burke JM, Gomes B.   +6 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura. [PDF]

CPT Pharmacometrics Syst Pharmacol
McBride C, Jiang J, Zhang Z, Tolsma J, Patwari P, Mellgård B, Vakilynejad M, Bhattacharya I, Zhu AZX.   +8 more
europepmc   +1 more source

Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Falkenhagen U, Knöchel J, Kloft C, Huisinga W.   +3 more
europepmc   +1 more source