Results 71 to 80 of about 55,223 (296)

Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression [PDF]

Genome Biology, 2005
AbstractHeritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). Transcribed RNA levels are often measured by hybridization to microarrays of oligonucleotide probes, in which each transcript is represented by multiple probes. The use of recombinant inbred lines allows an estimate of the heritability of expression
Manly, Kenneth F, Wang, Jintao, Williams, Robert W   +2 more
openaire   +2 more sources

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population

G3: Genes, Genomes, Genetics, 2023
Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (CC)
Gregory R Keele
doaj   +1 more source

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study [PDF]

Diabetologia, 2011
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using ...
Isomaa Bo, Isomaa B., Groop L., Lehtovirta M., Taskinen Marja-Riitta, Tuomi T., Isomaa B., Groop L., Lehtovirta M., Taskinen Marja-Riitta, Tuomi T.   +10 more
openaire   +2 more sources

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Heritability of Horn Size in Thinhorn Sheep

Frontiers in Genetics, 2019
Understanding the genetic basis of fitness-related trait variation has long been of great interest to evolutionary biologists. Secondary sexual characteristics, such as horns in bovids, are particularly intriguing since they can be potentially affected ...
Zijian Sim, Zijian Sim, David W. Coltman
doaj   +1 more source

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Variant level heritability estimates of type 2 diabetes in African Americans

Scientific Reports
Type 2 diabetes (T2D) is caused by both genetic and environmental factors and is associated with an increased risk of cardiorenal complications and mortality.
Nicole D. Armstrong, Amit Patki, Vinodh Srinivasasainagendra, Tian Ge, Leslie A. Lange, Leah Kottyan, Bahram Namjou, Amy S. Shah, Laura J. Rasmussen-Torvik, Gail P. Jarvik, James B. Meigs, Elizabeth W. Karlson, Nita A. Limdi, Marguerite R. Irvin, Hemant K. Tiwari   +14 more
doaj   +1 more source

Spring Is Coming: Genetic Analyses of the Bud Break Date Locus Reveal Candidate Genes From the Cold Perception Pathway to Dormancy Release in Apple (Malus × domestica Borkh.)

Frontiers in Plant Science, 2019
Chilling requirement (CR) for bud dormancy completion determines the time of bud break in apple (Malus × domestica Borkh.). The molecular control of bud dormancy is highly heritable, suggesting a strong genetic control of the trait. An available Infinium
Yohanna Evelyn Miotto, Carolina Tessele, Ana Beatriz Costa Czermainski, Diogo Denardi Porto, Vítor da Silveira Falavigna, Vítor da Silveira Falavigna, Tiago Sartor, Tiago Sartor, Amanda Malvessi Cattani, Amanda Malvessi Cattani, Carla Andrea Delatorre, Sérgio Amorim de Alencar, Orzenil Bonfim da Silva-Junior, Roberto Coiti Togawa, Marcos Mota do Carmo Costa, Georgios Joannis Pappas, Priscila Grynberg, Paulo Ricardo Dias de Oliveira, Marcus Vinícius Kvitschal, Frederico Denardi, Vanessa Buffon, Luís Fernando Revers, Luís Fernando Revers   +22 more
doaj   +1 more source

Genetics of the Inverse Relationship between Grain Yield and Grain Protein Content in Common Wheat

Plants, 2022
Grain protein content (GPC) is one of the most important criteria to determine the quality of common wheat (Triticum aestivum). One of the major obstacles for bread wheat production is the negative correlation between GPC and grain yield (GY).
Manuel Geyer, Volker Mohler, Lorenz Hartl   +2 more
doaj   +1 more source