Results 71 to 80 of about 3,366,415 (310)

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Environmental coupling of selection and heritability limits evolution [PDF]

, 2006
There has recently been great interest in applying theoretical quantitative genetic models to empirical studies of evolution in wild populations. However, while classical models assume environmental constancy, most natural populations exist in variable ...
T H Clutton-Brock, D W Coltman, Pemberton J. M, Coltman, D. W., J. G. Pilkington, A. J. Wilson, Pemberton, J. M., D. W. Coltman, J G Pilkington, L E B Kruuk, Mifsud, D. V., Coltman D. W, J. M. Pemberton, D V Mifsud, D. V. Mifsud, Clutton-Brock T. H, Pilkington, J. G., Pilkington J. G, Wilson, A. J., Kruuk, L. E. B., A J Wilson, L. E. B. Kruuk, Clutton-Brock, T. H., T. H. Clutton-brock, Wilson A. J, Mifsud D. V, Kruuk L. E. B, J M Pemberton   +27 more
core   +2 more sources

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Evolutionary dynamics of intratumor heterogeneity. [PDF]

PLoS ONE, 2011
Intraneoplastic diversity in human tumors is a widespread phenomenon of critical importance for tumor progression and the response to therapeutic intervention.
Yoh Iwasa, Franziska Michor
doaj   +1 more source

Trait-trait correlation.

, 2023
Different colors indicate the correlation level and the stars indicate the significant correlations after Bonferroni correction. a) Trait-trait correlation calculated from cell-disease associations in adult non-brain tissues.
Maor Sauler (10704568), Naftali Kaminski (27713), Daiwei Tang (12883199), Hongyu Zhao (4728), Louise V. Wain (7588511), Ming Chen (115604), Zihan Dong (3334086), Wei Liu (20030), Michael H. Cho (6856079), Biqing Zhu (8861003), Chen Lin (95910), Wenxuan Deng (14853814), Zhaolong Yu (11404632)   +12 more
core   +1 more source

Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression [PDF]

Genome Biology, 2005
AbstractHeritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). Transcribed RNA levels are often measured by hybridization to microarrays of oligonucleotide probes, in which each transcript is represented by multiple probes. The use of recombinant inbred lines allows an estimate of the heritability of expression
Manly, Kenneth F, Wang, Jintao, Williams, Robert W   +2 more
openaire   +2 more sources

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population

G3: Genes, Genomes, Genetics, 2023
Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (CC)
Gregory R Keele
doaj   +1 more source

Detection of quantitative trait loci for locomotion and osteochondrosis-related traits in Large White x Meishan pigs. [PDF]

, 2003
Data from the F2 generation of a Large White (LW) 5 Meishan (MS) crossbred population were analysed to detect quantitative trait loci (QTL) for leg and gait scores, osteochondrosis and physis scores.
Lee, G. J., Law, Andy, Archibald, Alan, Nicholson, D, Haley, Chris, Garth, G. B., Barr, A.   +6 more
core  

Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits [PDF]

Genes, Brain and Behavior, 2017
Humans exhibit broad heterogeneity in affiliative social behavior. Twin and family studies show that individual differences in core dimensions of social behavior are heritable, yet there are knowledge gaps in understanding the underlying genetic and neurobiological mechanisms.
Knoll, A. T., Jiang, K., Levitt, P.
openaire   +2 more sources