Results 61 to 70 of about 3,521,649 (161)

Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

Translational Psychiatry, 2022
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment.
Nora I. Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath   +22 more
doaj   +1 more source

Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis

eLife, 2019
Variation in DNA methylation enables plants to inherit traits independently of changes to DNA sequence. Here, we have screened an Arabidopsis population of epigenetic recombinant inbred lines (epiRILs) for resistance against Hyaloperonospora ...
Leonardo Furci, Ritushree Jain, Joost Stassen, Oliver Berkowitz, James Whelan, David Roquis, Victoire Baillet, Vincent Colot, Frank Johannes, Jurriaan Ton   +9 more
doaj   +1 more source

Evolutionary dynamics of intratumor heterogeneity. [PDF]

PLoS ONE, 2011
Intraneoplastic diversity in human tumors is a widespread phenomenon of critical importance for tumor progression and the response to therapeutic intervention.
Yoh Iwasa, Franziska Michor
doaj   +1 more source

Variant level heritability estimates of type 2 diabetes in African Americans

Scientific Reports
Type 2 diabetes (T2D) is caused by both genetic and environmental factors and is associated with an increased risk of cardiorenal complications and mortality.
Nicole D. Armstrong, Amit Patki, Vinodh Srinivasasainagendra, Tian Ge, Leslie A. Lange, Leah Kottyan, Bahram Namjou, Amy S. Shah, Laura J. Rasmussen-Torvik, Gail P. Jarvik, James B. Meigs, Elizabeth W. Karlson, Nita A. Limdi, Marguerite R. Irvin, Hemant K. Tiwari   +14 more
doaj   +1 more source

Genetics of the Inverse Relationship between Grain Yield and Grain Protein Content in Common Wheat

Plants, 2022
Grain protein content (GPC) is one of the most important criteria to determine the quality of common wheat (Triticum aestivum). One of the major obstacles for bread wheat production is the negative correlation between GPC and grain yield (GY).
Manuel Geyer, Volker Mohler, Lorenz Hartl   +2 more
doaj   +1 more source

Ecological consequences of heritable intraspecific variation [PDF]

, 2021
Trait variation among individuals of a population is now considered to be an important part of biodiversity. Many empirical studies have quantified this variation and showed that it can change over time.
Senthilnathan, Athmanathan
core  

Heritability of Horn Size in Thinhorn Sheep

Frontiers in Genetics, 2019
Understanding the genetic basis of fitness-related trait variation has long been of great interest to evolutionary biologists. Secondary sexual characteristics, such as horns in bovids, are particularly intriguing since they can be potentially affected ...
Zijian Sim, Zijian Sim, David W. Coltman
doaj   +1 more source

Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population

G3: Genes, Genomes, Genetics, 2023
Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (CC)
Gregory R Keele
doaj   +1 more source

Spring Is Coming: Genetic Analyses of the Bud Break Date Locus Reveal Candidate Genes From the Cold Perception Pathway to Dormancy Release in Apple (Malus × domestica Borkh.)

Frontiers in Plant Science, 2019
Chilling requirement (CR) for bud dormancy completion determines the time of bud break in apple (Malus × domestica Borkh.). The molecular control of bud dormancy is highly heritable, suggesting a strong genetic control of the trait. An available Infinium
Yohanna Evelyn Miotto, Carolina Tessele, Ana Beatriz Costa Czermainski, Diogo Denardi Porto, Vítor da Silveira Falavigna, Vítor da Silveira Falavigna, Tiago Sartor, Tiago Sartor, Amanda Malvessi Cattani, Amanda Malvessi Cattani, Carla Andrea Delatorre, Sérgio Amorim de Alencar, Orzenil Bonfim da Silva-Junior, Roberto Coiti Togawa, Marcos Mota do Carmo Costa, Georgios Joannis Pappas, Priscila Grynberg, Paulo Ricardo Dias de Oliveira, Marcus Vinícius Kvitschal, Frederico Denardi, Vanessa Buffon, Luís Fernando Revers, Luís Fernando Revers   +22 more
doaj   +1 more source

Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross [PDF]

, 2007
An F-2 broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits.
Sharman, P. W. A., Morrice, D. R., Law, A. S., Hocking, P. M., Burt, D. W.   +4 more
core   +1 more source