Results 61 to 70 of about 55,223 (296)

Future trends in Animal Breeding due to new genetic tecnologies

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis

eLife, 2019
Variation in DNA methylation enables plants to inherit traits independently of changes to DNA sequence. Here, we have screened an Arabidopsis population of epigenetic recombinant inbred lines (epiRILs) for resistance against Hyaloperonospora ...
Leonardo Furci, Ritushree Jain, Joost Stassen, Oliver Berkowitz, James Whelan, David Roquis, Victoire Baillet, Vincent Colot, Frank Johannes, Jurriaan Ton   +9 more
doaj   +1 more source

Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

Translational Psychiatry, 2022
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment.
Nora I. Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath   +22 more
doaj   +1 more source

Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence : The Generation Scotland Study [PDF]

, 2014
Creative Commons Attribution LicensePeer reviewedPublisher ...
Archie Campbell, B Benyamin, BH Smith, BH Smith, C Gale, Caroline Hayward, CM Calvin, CM Calvin, CM Haworth, CM Lee, D Wechsler, D Wechsler, David J. Porteous, E Whitley, G Davies, G. David Batty, GD Batty, Ian J. Deary, IJ Deary, IJ Deary, J Yang, J Yang, JC Raven, JM Starr, JM Sundet, JP Beauchamp, K Silventoinen, K Silventoinen, KL Gunderson, LJ Whalley, Lynne J. Hocking, M Trzaskowski, MC Keller, MD Lezak, Peter M. Visscher, Riccardo E. Marioni, S Macgregor, SH Lee, Shona M. Kerr, SM Kerr, TA Paajanen   +40 more
core   +3 more sources

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Epigenetic regulation of adaptive responses of forest tree species to the environment [PDF]

, 2013
Epigenetic variation is likely to contribute to the phenotypic plasticity and adaptative capacity of plant species, and may be especially important for long-lived organisms with complex life cycles, including forest trees.
Abarca, Dolores, Bräutigam, Katharina, Campbell, Malcolm M., Cervera, María-Teresa, Díaz-Sala, Carmen, Fluch, Silvia, Fossdal, Carl G., Fraga, Mario Fernández, Guevara, M. Ángeles, Johnsen, Øystein, Jose, Gutiérrez-Marcos, Lafon-Placette, Clément, Maury, Stéphane, Mirouze, Marie, Rohde, Antje, Strauss, Steven H., Vining, Kelly J.   +16 more
core   +4 more sources

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Evolutionary dynamics of intratumor heterogeneity. [PDF]

PLoS ONE, 2011
Intraneoplastic diversity in human tumors is a widespread phenomenon of critical importance for tumor progression and the response to therapeutic intervention.
Yoh Iwasa, Franziska Michor
doaj   +1 more source

Rare variants contribute disproportionately to quantitative trait variation in yeast. [PDF]

, 2019
How variants with different frequencies contribute to trait variation is a central question in genetics. We use a unique model system to disentangle the contributions of common and rare variants to quantitative traits.
Bloom, Joshua S, Boocock, James, Day, Laura, Kruglyak, Leonid, Oates-Barker, Holly, Sadhu, Meru J, Treusch, Sebastian   +6 more
core   +1 more source