Results 61 to 70 of about 3,366,415 (310)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Disease resistance in Atlantic salmon (Salmo salar): coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi. [PDF]

PLoS ONE, 2014
BACKGROUND: Naturally occurring coinfections of pathogens have been reported in salmonids, but their consequences on disease resistance are unclear. We hypothesized that 1) coinfection of Caligus rogercresseyi reduces the resistance of Atlantic salmon to
Jean Paul Lhorente, José A Gallardo, Beatriz Villanueva, María J Carabaño, Roberto Neira   +4 more
doaj   +1 more source

QTL detection and allelic effects for growth and fat traits in outbred pig populations [PDF]

, 2004
Quantitative trait loci (QTL) for growth and fatness traits have previously been identified on chromosomes 4 and 7 in several experimental pig populations.
Haley, CS, Visscher, Peter M, Chris S Haley, Nagamine, Y, Peter M. Visscher, Haley, Chris, Nagamine, Yoshitaka, Haley, Chris S, Peter M Visscher, Visscher Peter M, Visscher, PM, Chris S. Haley, Yoshitaka Nagamine, Visscher, Peter, Nagamine Yoshitaka, Haley Chris S   +15 more
core   +1 more source

Heterochromatin is a quantitative trait associated with spontaneous epiallele formation

, 2021
first release of analysis code for the paper "Heterochromatin is a quantitative trait associated with spontaneous epiallele ...
Frank Johannes, Hosung Jang, Robert S. Piecyk, Rui Xiao, Yinwen Zhang, Ioanna Kakoulidou, Robert J. Schmitz   +6 more
core   +1 more source

Directional Latent Hybridization: Beyond Random Noise in Physics‐Informed Generative Inverse Design of Nonlinear Metamaterials

Advanced Materials Technologies, EarlyView.
A physics‐informed generative framework introduces Directional Latent Hybridization (DLH) for the deterministic inverse design of nonlinear metamaterials. By hybridizing dominant traits from parent geometries in the latent space, DLH overcomes the instabilities of stochastic models to ensure high structural precision at high densities.
Semin Ahn, Jun Young Choi, Sung‐Hoon Ahn   +2 more
wiley   +1 more source

Linkage analysis of a model quantitative trait in humans: finger ridge count shows significant multivariate linkage to 5q14.1.

PLoS Genetics, 2007
The finger ridge count (a measure of pattern size) is one of the most heritable complex traits studied in humans and has been considered a model human polygenic trait in quantitative genetic analysis.
Sarah E Medland, Danuta Z Loesch, Bogdan Mdzewski, Gu Zhu, Grant W Montgomery, Nicholas G Martin   +5 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis

eLife, 2019
Variation in DNA methylation enables plants to inherit traits independently of changes to DNA sequence. Here, we have screened an Arabidopsis population of epigenetic recombinant inbred lines (epiRILs) for resistance against Hyaloperonospora ...
Leonardo Furci, Ritushree Jain, Joost Stassen, Oliver Berkowitz, James Whelan, David Roquis, Victoire Baillet, Vincent Colot, Frank Johannes, Jurriaan Ton   +9 more
doaj   +1 more source

Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

Translational Psychiatry, 2022
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment.
Nora I. Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath   +22 more
doaj   +1 more source

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study [PDF]

Diabetologia, 2011
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using ...
Isomaa B., Groop L., Lehtovirta M., Taskinen Marja-Riitta, Tuomi T., Isomaa Bo, Isomaa B., Groop L., Lehtovirta M., Taskinen Marja-Riitta, Tuomi T.   +10 more
openaire   +2 more sources